Results 191 to 200 of about 1,543,622 (248)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol. [PDF]

BMJ Open
Wenje SM, Calvert S, Henshaw H, Spriggs RV, Dening T, Hendron E, Heffernan E.   +6 more
europepmc   +1 more source

Primary Care Clinical Practice Guidelines and Referral Pathways for Oral and Dental Diseases in Pakistan [PDF]

S Haider, Russell Seth Martins, Rohaid Ali, Nashia Ali Rizvi, Ali Mustafa, Salima Saleem Aamdani, Alina Abdul Rehman, Alina Pervez, Sarah Nadeem, Humayun Kaleem Siddiqui, A. Sadiq, Syed Murtaza Raza Kazmi, Adil H. Haider, Fahad Umer   +13 more
openalex   +1 more source

Radiation-Induced Apoptosis: The Ceramide-SAPK Signaling Pathway and Clinical Aspects [PDF]

, 1998
Marcel Verheij, Wim J. van Blitterswijk, Harry Bartelink   +2 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

WHO Workshop Report: Regulatory Science to Inform Clinical Pathways for Shigella Vaccines Intended for Use in Children in Low- and Middle-Income Countries. [PDF]

Vaccines (Basel)
Kaminski RW, Pavlinac PB, Platts-Mills JA, Rogawski McQuade ET, Hausdorff WP, Isbrucker RA, Vannice KS, Cavaleri M, Kochhar S, Mehring-LeDoare K, Enwere G, Wilder-Smith A, Kotloff KL, Sow S, Giersing BK.   +14 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Development and validity testing of a matrix to evaluate maturity of clinical pathways: a case study in Saskatchewan, Canada. [PDF]

BMC Health Serv Res
Larson CL, Vanstone JR, Mise TR, Tupper SM, Groot G, Azizian AR.   +5 more
europepmc   +1 more source

Pathway analysis of clinical nurse educator’s intention to use virtual reality technology based on the UTAUT model [PDF]

Meng‐Ying Li, Fu Dongquan, Li‐Chan Lin, Cao Yining, HE Hui-juan, Zhou Siyu, Dan Yin   +6 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source