Results 231 to 240 of about 8,138,914 (303)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Identifying Key Variances in Clinical Pathways Associated With Prolonged Hospital Stays Using Machine Learning and ePath Real-World Data: Model Development and Validation Study. [PDF]

JMIR Med Inform
Tou S, Matsumoto K, Hashinokuchi A, Kinoshita F, Nohara Y, Yamashita T, Wakata Y, Takenaka T, Soejima H, Yoshizumi T, Nakashima N, Kamouchi M.   +11 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Clinical pathways for secondary care and the effects on professional practice, patient outcomes, length of stay and hospital costs. [PDF]

Cochrane Database Syst Rev
Rotter T, Kinsman LD, Alsius A, Scott SD, Lawal A, Ronellenfitsch U, Plishka C, Groot G, Woods P, Coulson C, Bakel LA, Sears K, Ross-White A, Machotta A, Schultz TJ.   +14 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Primary Central Nervous System Tumors in Adolescents: A Population-Based Study on Epidemiology and Clinical Pathways in a Challenging Age Group. [PDF]

Curr Oncol
De Martino L, Piga P, Sessa M, Calì C, Russo C, Picariello S, Onorini N, Spennato P, Quaglietta L, Donofrio MV, Cinalli G, Vetrano F, Savoia F.   +12 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Specialist clinical pathways in audiology services for adults living with coexisting hearing loss and dementia: a scoping review protocol. [PDF]

BMJ Open
Wenje SM, Calvert S, Henshaw H, Spriggs RV, Dening T, Hendron E, Heffernan E.   +6 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

WHO Workshop Report: Regulatory Science to Inform Clinical Pathways for Shigella Vaccines Intended for Use in Children in Low- and Middle-Income Countries. [PDF]

Vaccines (Basel)
Kaminski RW, Pavlinac PB, Platts-Mills JA, Rogawski McQuade ET, Hausdorff WP, Isbrucker RA, Vannice KS, Cavaleri M, Kochhar S, Mehring-LeDoare K, Enwere G, Wilder-Smith A, Kotloff KL, Sow S, Giersing BK.   +14 more
europepmc   +1 more source