Results 241 to 250 of about 8,138,914 (303)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Development and validity testing of a matrix to evaluate maturity of clinical pathways: a case study in Saskatchewan, Canada. [PDF]

BMC Health Serv Res
Larson CL, Vanstone JR, Mise TR, Tupper SM, Groot G, Azizian AR.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Clinical pathways for Korean medicine: An implementation approach to impact on the clinical process and association with attitudes. [PDF]

Heliyon
Hyun E, Kim H, Kwak HY, Kim D.
europepmc   +1 more source

Management of nonurgent common gastroenterology referrals using primary care clinical pathways: Clinical outcomes, health care use, and avoided costs. [PDF]

Can Fam Physician
Novak K, Qureshi A, Carter J, Mazurek M, Belletrutti PJ, Maracle B, Heitman SJ, van Zanten SV, Swain M, Jelinski SE.   +9 more
europepmc   +1 more source

Clinical pathways and operations management: it takes two to tango. [PDF]

Belien, Jeroen, Cardoen, Brecht, Sermeus, Walter, Demeulemeester, Erik   +3 more
core  

RETRACTED: A systematic genomic screen of 755 early-onset Parkinson’s patients from the 100,000 Genomes Project increases diagnostic yield and directs clinical pathways

Newbury DF, Sabu N, Hussein ESH, Taylor JC.   +3 more
europepmc   +1 more source