Results 51 to 60 of about 1,543,622 (248)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Advocating for an integrated healthcare model for women of reproductive age in low- and middle-income countries

Critical Public Health
Increasingly, women are presenting in pregnancy with multi-risk and multi-morbidity profiles (combinations of pro-inflammatory diets, trauma, anxiety, depression, infections, metabolic disease, and chronic medication use); together these may ...
Lauren Stuart, Rachana Desai, Claire Hart, Shane A. Norris   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways

, 2022
Kübra Karagoz, Matthew P. Stokes, María Ortiz-Estévez, Fadi Towfic, Erin Flynt, Sarah Gooding, William E. Pierceall, Anjan Thakurta   +7 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Young women’s social support networks during pregnancy in Soweto, South Africa

African Journal of Primary Health Care & Family Medicine
Background: Although studies from high-income countries have examined social support during pregnancy, it remains unclear what type of support is received by expectant mothers from low- and middle-income country settings.
Khuthala Mabetha, Larske M. Soepnel, Sonja Klingberg, Gugulethu Mabena, Molebogeng Motlhatlhedi, Shane A Norris, Catherine E. Draper   +6 more
doaj   +1 more source

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma [PDF]

, 2021
Vid Mlakar, Edouard Morel, Simona Jurković Mlakar, Marc Ansari, Fabienne Gumy‐Pause   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Epidemiology of respiratory syncytial virus in a large pediatric hospital in Central Italy and development of a forecasting model to predict the seasonal peak

Italian Journal of Pediatrics
Background Respiratory Syncytial Virus (RSV) is responsible for the majority of acute lower respiratory infections in infants and can affect also older age groups.
Renato Cutrera, Marta Luisa Ciofi degli Atti, Andrea Dotta, Carmen D’Amore, Lucilla Ravà, Carlo Federico Perno, Alberto Villani   +6 more
doaj   +1 more source

Boikoetliso Ba Boko (‘exercising the mind’): protocol for a mixed methods feasibility and acceptability study of a prototype mental health intervention for adolescents and young people with anxiety and depression

Frontiers in Child and Adolescent Psychiatry
BackgroundApproximately one in four adolescents in Sub-Saharan Africa experiences significantly elevated symptoms of anxiety and depression. Those living in resource-constrained communities face heightened risks due to acute distress, trauma, and less ...
Claire Hart, Rachana Desai, Lauren Stuart, Shane A. Norris, Shane A. Norris   +4 more
doaj   +1 more source