Results 71 to 80 of about 8,138,914 (303)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Examining maternal health literacy as a mediator of the relationship between social vulnerability and caregiving practices for improving infant development

BMC Public Health
This study examined whether specific dimensions of maternal health literacy mediated the relationship between social vulnerability and maternal caregiving confidence, specifically breastfeeding self-efficacy and maternal beliefs about play, among 168 ...
Lauren Stuart, Claire Hart, Rachana Desai, Shane A. Norris, Fiona Bennin, Helene Theunissen, Alessandra Prioreschi   +6 more
doaj   +1 more source

The Business Process Model and Notation Used for the Representation of Alzheimer’s Disease Patients Care Process

Data, 2020
Currently, the number of patients with neurological diseases is increasing, especially those older than 65 suffering from Alzheimer’s disease. This development increases the emphasis on understanding and mapping treatment and care processes, not ...
Martin Kopecky, Hana Tomaskova
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Gut Microbial Signatures Associated with Cryptosporidiosis: A Case Series

Microorganisms
Cryptosporidium spp. are zoonotic protozoan parasites with a global prevalence, with both gastrointestinal and pulmonary involvement. Though symptoms can often be relatively mild, they can become severe and even fatal in children under five, the elderly,
Antonia Piazzesi, Stefania Pane, Lorenza Romani, Francesca Toto, Matteo Scanu, Riccardo Marsiglia, Federica Del Chierico, Nicola Cotugno, Paolo Palma, Lorenza Putignani   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluating the capacity of clinical pathways through discrete-event simulation. [PDF]

Organizing a medical facility efficiently is hard due to the numerous patient trajectories and their use of joint and scarce resources. Moreover, these trajectories tend to be complex and characterized by uncertain medical processes.
Cardoen, Brecht, Demeulemeester, Erik
core  

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Edwards, J., Bartlett, J.M.S.
core   +1 more source

Risk and Protective Factors for Executive Function in Vulnerable South African Preschool-Age Children

Journal of Cognition
Executive function (EF) theory and research continues to under-represent the contexts in which the majority of the world’s children reside, despite their potential to support, refute, or refine our current understandings.
Caylee J. Cook, Steven J. Howard, Hleliwe Makaula, Rebecca Merkley, Mbulelo Mshudulu, Nosibusiso Tshetu, Gaia Scerif, Catherine E. Draper   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source