Results 61 to 70 of about 8,138,914 (303)

Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer [PDF]

, 2017
Wee1 is a protein kinase that regulates the G2checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 serine/threonine protein kinases that coordinate the progression through the cell cycle.
Geenen, Jill J., Schellens, Jan H M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology   +3 more
core   +2 more sources

The Use of ABILHAND-Kids in Children with Unilateral Congenital Below-Elbow Deficiencies and Acquired Amputation: An Italian Cross-Sectional Study

Children
Congenital or acquired hand differences, including unilateral below-elbow deficiencies, present complex challenges in pediatric rehabilitation. Surgical management and prosthetic provision represent a big challenge to find a good balance for guaranteeing
Gessica Della Bella, Luigino Santecchia, Paola Luttazi, Giordana Mariani, Lorenzo Pochiero, Alessandra Lacopo, Caterina Delia, Marco Tofani   +7 more
doaj   +1 more source

New clinical pathways for keratoconus [PDF]

Eye, 2012
Pre-2000, the clinical management of keratoconus centred on rigid contact lens fitting when spectacle corrected acuity was no longer adequate, and transplantation where contact lens wear failed. Over the last decade, outcome data have accumulated for new interventions including corneal collagen crosslinking, intracorneal ring implantation, topographic ...
D M, Gore, A J, Shortt, B D, Allan
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evaluating the Global Intensive Feeding Therapy (GIFT) for Children with CHARGE Syndrome: A Quasi-Experimental Study

Children
Background: This pilot investigation aimed to evaluate the efficacy of Global Intensive Feeding Therapy (GIFT) on feeding and swallowing abilities in children with CHARGE Syndrome (CS).
Antonella Cerchiari, Francesca Pizza, Giorgia Biondo, Carolina Giordani, Martina De Paolis, Gessica Della Bella, Massimiliano Raponi, Marco Tofani   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The role of a community health worker-delivered preconception and pregnancy intervention in achieving a more positive pregnancy experience: the Bukhali trial in Soweto, South Africa

BMC Women's Health
Background A patient-centered, human-rights based approach to maternal care moves past merely reducing maternal mortality and morbidity, towards achieving a positive pregnancy experience.
Larske M. Soepnel, Khuthala Mabetha, Shane A. Norris, Molebogeng Motlhatlhedi, Nokuthula Nkosi, Sonja Klingberg, Stephen Lye, Catherine E. Draper   +7 more
doaj   +1 more source

Effectiveness and Sustainability of an Antimicrobial Stewardship Program for Perioperative Prophylaxis in Pediatric Surgery

Pathogens, 2020
Background—Appropriate perioperative antibiotic prophylaxis (PAP) is essential to prevent surgical site infections (SSIs) and to avoid antibiotics misuse.
Daniele Donà, Dora Luise, Elisa Barbieri, Nicola Masiero, Sonia Maita, Luca Antoniello, Theoklis Zaoutis, Carlo Giaquinto, Piergiorgio Gamba   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Procedural sedation in dentistry: a scoping review and proposal for an ad hoc informed consent

BMC Medical Ethics
Background The healthcare aspects of dentistry are framed within a legal environment. Dentists are obliged to obtain their patients’ written informed consent (IC) before undertaking any procedures.
Angela Galeotti, Alessandra Putrino, Annelyse Martine Garret-Bernardin, Martina Caputo, Sonia Vanacore, Maria Lodise, Chiara Siodambro, Giovanni Battista Grossi, Matteo Pellegrini, Gastone Zanette, Ferruccio Morandi   +10 more
doaj   +1 more source