Results 51 to 60 of about 8,138,914 (303)

Management by geographic area or management specialised by disorder? A mixed-methods evaluation of the effects of an organisational intervention on secondary mental health care for common mental disorder [PDF]

, 2016
In 2010, South London and Maudsley NHS Foundation Trust (SLaM) established a programme replacing the borough directorates responsible for adult mental health services with three Clinical Academic Groups (CAGs), each of which took on a subset of adult ...
Khondoker, Mizanur, Thornicroft, G, Rose, Diana, Anke Görzig, Sophie Pettit, Tulloch, Alex D, McCrone, P, Thornicroft, Graham, Leonardo Koeser, Graham Thornicroft, Tylee, A, Paul McCrone, Görzig, Anke, Tulloch, Alex, Polling, C; id_orcid, Andrew Watson, Diana Rose, Pettit, S, Tylee, Andre, Bryony Soper, Koeser, L; id_orcid, Watson, Andrew, Catherine Polling, Koeser, Leonardo, Alex D Tulloch, Rose, D, Görzig, A, Pettit, Sophie, Mizanur Khondoker, André Tylee, McCrone, Paul, Polling, Catherine, Tulloch, A D, Watson, A, Soper, B, Soper, Bryony, Khondoker, M   +36 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Cardiorespiratory fitness levels and associations with physical activity and body composition in young South African adults from Soweto

BMC Public Health, 2017
Background This observational study aims to describe fitness, and objectively measured physical activity levels and patterns in 409 young black South African adults (aged 19–20 years) from Soweto, as well as to examine associations between physical ...
A. Prioreschi, S. Brage, K. Westgate, S. A. Norris, L. K. Micklesfield   +4 more
doaj   +1 more source

Measuring clinical pathway adherence

Journal of Biomedical Informatics, 2010
As clinical pathway adoption continues worldwide, it is necessary to establish adherence measurement methods in order to understand the difficulties and results of implementation. Adherence measurement literature mostly provides binary measurements of adherence to guidelines regarding individual medical activities over patient groups.
Joris van de Klundert, Pascal Gorissen, Stef Zeemering   +2 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Early clinical development of targeted anticancer agents [PDF]

, 2017
Van Brummelen studied the safety and preliminary signs of efficacy of several novel targeted anticancer agents in phase I trials. In her thesis, she reports the results of trials with the immunotherapies pembrolizumab and cergutuzumab-amunaleukin, and ...
van Brummelen, E.M.J., Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology   +2 more
core  

Clinical pathways and quality metrics.

, 2014
273 Background: UPMC CancerCenter (UPMC) participates in a number of nationally recognized quality programs and strives to maximize quality through continuous improvement of the quality measures endorsed by these programs.
Peter G. Ellis, Kathleen Lokay
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

HSE National Centre for Clinical Audit Clinical Audit – A Practical Guide

, 2023
This document replaces the previously published “A Practical Guide to Clinical Audit” (HSE 2013). It forms part of a series of resources being developed to support services and all healthcare professionals to ensure the continuation and development of ...
HSE National Centre for Clinical Audit
core