Results 131 to 140 of about 914,658 (345)

Parenteral glucose supply and pharmacological glycolysis inhibition determine the clinical fate of infected preterm newborns [PDF]

, 2021
Tik Muk, Anders Brunse, Nicole Lind Henriksen, Karoline Aasmul‐Olsen, Duc Ninh Nguyen   +4 more
openalex   +1 more source

Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium [PDF]

, 2009
Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein.
Daminet, Sylvie, Erkens, Tim, Gommeren, Kris, Lampo, Evelyne, Peelman, Luc, Rogiers, Carolien, Van den Broeke, Alice, Van Poucke, Mario, Van Zeveren, Alex, Vander Donckt, Dominique   +9 more
core   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Phytopharmacology: at the origins of pharmacy and clinical pharmacology

Фармакокинетика и Фармакодинамика, 2014
Article is devoted to historical review of pharmacology and pharmacy herbal medicines since ancient times.
D. A. Sychev, K. V. Gerasimov, D. U. Belousov   +2 more
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Journal of Population and Therapeutics and Clinical Pharmacology

, 2023
Shahrukh Irfan, Syed Aziz Uddin, Fatima Riaz, Muhammad Mubeen Arshad, Hareem Abdul Sattar, Syed Akbar Abbas Zaidi, Anum Arshad, Naina Devi, Shahzad Baloch   +8 more
openalex   +1 more source

The Comparison of Gabapentin and Amitriptilin Effectivity as Pain Therapy in Herniated Nucleus Pulposus [PDF]

, 2015
Herniated nucleus pulposus (HNP) is one of peripheral neuropathic pain. Although concensus guidelines for the treatment of neuropathic pain are based on the results of the RCT studies, there are still gaps in the literatures.
Cahyaningsih, I. (Indriastuti), Handayani, R. (Rina), Setyaningsih, S. (Setyaningsih)   +2 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Pharmacoeconomics as an instrument of clinical pharmacology for optimization of pharmacotherapy (review)

Регуляторные исследования и экспертиза лекарственных средств, 2018
Pharmacoeconomics is an essential component of health technology assessment and the appraisal of medicines for use by patients. As a comparatively young discipline, its methods continue to evolve.
O. V. Reshet'ko, K. A. Lutsevich
doaj  

Large Language Models and Their Applications in Drug Discovery and Development: A Primer

Clinical and Translational Science
Large language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs to these disciplines.
James Lu, Keunwoo Choi, Maksim Eremeev, Jogarao Gobburu, Srijib Goswami, Qi Liu, Gary Mo, Cynthia J. Musante, Mohamed H. Shahin   +8 more
doaj   +1 more source