Clinical pharmacology and therapeutics of the oesophagus and the lower oesophageal sphincter
J J Misiewicz
openalex +1 more source
To be or not to be, when synthetic data meet clinical pharmacology: A focused study on pharmacogenetics. [PDF]
Woillard JB+6 more
europepmc +1 more source
Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang+16 more
wiley +1 more source
The Clinical Neuromuscular Pharmacology of Mivacurium Chloride (BW B1090U). A Short-acting Nondepolarizing Ester Neuromuscular Blocking Drug [PDF]
John J. Savarese+8 more
openalex +1 more source
Dynamics of thrombin generation: Filling the gap between the system pharmacology theory and clinical practice in clinical pharmacology and therapeutics. [PDF]
Ruiz L+7 more
europepmc +1 more source
Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker
The study detects a potential multimodal biomarker that can be promising for identifying early markers of psychosis. It shows a consistent brain‐behavior association between a circuit of interconnected regions and executive function in neurotypical controls and individuals at various stages of psychosis.
Leonardo Fazio+22 more
wiley +1 more source
The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni+16 more
wiley +1 more source
Clinical Pharmacology of Cytokine Release Syndrome with T-Cell-Engaging Bispecific Antibodies: Current Insights and Drug Development Strategies. [PDF]
Radtke KK+6 more
europepmc +1 more source