Results 271 to 280 of about 914,658 (345)

AI-Driven Applications in Clinical Pharmacology and Translational Science: Insights From the ASCPT 2024 AI Preconference. [PDF]

Clin Transl Sci
Shahin MH, Desai P, Terranova N, Guan Y, Helikar T, Lobentanzer S, Liu Q, Lu J, Madhavan S, Mo G, Musuamba FT, Podichetty JT, Shen J, Xie L, Wiens M, Musante CJ.   +15 more
europepmc   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Clinical pharmacology in adolescent transgender medicine. [PDF]

Br J Clin Pharmacol
Cirrincione LR, Huang KJ, Sequeira GM.
europepmc   +1 more source

Differential pharmacology and clinical utility of sonidegib in advanced basal cell carcinoma

, 2017
Mohd Wahid, Arshad Jawed, Sajad Ahmad Dar, Raju K. Mandal, Shafiul Haque   +4 more
openalex   +2 more sources

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Reducing carbon, enhancing care: the future of sustainable medicine

Frontiers in Pharmacology
Alessio Provenzani, Mia Como, Gennaro Martucci   +2 more
doaj   +1 more source

Agents for Change: Artificial Intelligent Workflows for Quantitative Clinical Pharmacology and Translational Sciences. [PDF]

Clin Transl Sci
Shahin MH, Goswami S, Lobentanzer S, Corrigan BW.   +3 more
europepmc   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Self‐Powered Permeable Electronic Dressing for Exudate Management, Electrostimulation and Drug Delivery in Chronic Wound Healing

Advanced Functional Materials, EarlyView.
This study develops a self‐powered permeable electronic dressing (SPED) that synergistically integrates exudate management, electrical stimulation, and on‐demand drug delivery. The dressing effectively absorbs exudate while demonstrating potent antibacterial activity and accelerated tissue regeneration in diabetic mouse models, thereby promoting ...
Jiaheng Liang, Jingjing Fu, Jin Chai, Hongyu Jiang, Fan Chen, Yufei Zhang, Weihao Zhao, Xian Song, Zhihao Zhou, Lingtao Fang, Qiyao Huang, Peng Li, Zijian Zheng   +12 more
wiley   +1 more source

Applying the estimand framework to clinical pharmacology trials with a case study in bioequivalence. [PDF]

Br J Clin Pharmacol
Lynggaard H, McKendrick S, Baird M, Kerwash E, Lanius V, Lasch F, Wright D.   +6 more
europepmc   +1 more source