Results 61 to 70 of about 857,003 (376)

N-acetylcysteine for non-acetaminophen induced acute liver failure: A review

The Saudi Journal of Gastroenterology, 2022
The use of N-acetylcysteine (NAC) for non-acetaminophen-induced acute liver failure (NAI-ALF) has been increasing despite controversy in its efficacy.
Shirley Xue Jiang, Trana Hussaini, Eric M. Yoshida   +2 more
doaj   +1 more source

VDDB: a comprehensive resource and machine learning platform for antiviral drug discovery [PDF]

arXiv, 2022
Virus infection is one of the major diseases that seriously threaten human health. To meet the growing demand for mining and sharing data resources related to antiviral drugs and to accelerate the design and discovery of new antiviral drugs, we presented an open-access antiviral drug resource and machine learning platform (VDDB), which, to the best of ...
arxiv  

Clinical Pharmacology of Mezlocillin [PDF]

Antimicrobial Agents and Chemotherapy, 1978
Mezlocillin is a new broad-spectrum semisynthetic penicillin that has shown encouraging in vitro activity against the infecting organisms most likely to cause mortality and morbidity in cancer patients receiving chemotherapy. The serum clearances and urine recoveries of mezlocillin, ampicillin, and carbenicillin were compared after the intravenous ...
Susanne S. Weaver, Brian F. Issell, Gerald P. Bodey   +2 more
openaire   +3 more sources

Sex disparities in the effect of statins on lipid parameters:The PharmLines Initiative [PDF]

, 2022
Real-world evidence on a potential statin effect modification by sex is inconclusive, especially for the primary prevention of cardiovascular disease (CVD). We aimed to quantify the differences in the effect of statins on lipid parameters between men and
Afd Pharmacoepi & Clinical Pharmacology, Bos, Jens H J, de Boer, Rudolf A, de Vos, Stijn, Emmens, Johanna E, Hak, Eelko, Hunt, Nicholas B, Irawati, Sylvi, Pharmacoepidemiology and Clinical Pharmacology, Wilffert, Bob   +9 more
core   +4 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Decision making under uncertainty: comparing regulatory and health technology assessment reviews of medicines in the United States and Europe [PDF]

, 2020
Assessments of clinical evidence vary between regulators and health technology assessment bodies, but precise differences remain unclear. To compare uncertainties raised on the clinical evidence of approved drugs, we analyzed assessments of regulators ...
Afd Pharmacoepi & Clinical Pharmacology, Goettsch, Wim G., Kesselheim, Aaron S., Leufkens, Hubert G.M., Mantel-Teeuwisse, Aukje K., Naci, Huseyin, Pharmacoepidemiology and Clinical Pharmacology, Schneeweiss, Sebastian G., Vreman, Rick A.   +8 more
core   +2 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Clinical Pharmacology

British Journal of Clinical Pharmacology, 2003
P. N. Bennett & M. J. Brown 
Published by Churchill Livingstone, Edinburgh 
ISBN 0‐443‐06480‐6. Price: £39.99.
openaire   +5 more sources

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT) is an established voice of the discipline, a trusted source of new knowledge showcasing discovery, translation, and application of novel therapeutic paradigms to advance the management of patients and ...
Terzic, Andre M., Waldman, Scott A.
core   +2 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source