Results 41 to 50 of about 519,368 (313)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

, 2017
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine ...
Schellens, Jan H M, Swen, Jesse J, Klein, T.E., Julia Barbarino, Kelly E. Caudle, Diasio, R.B., Caudle, K.E., Steven M. Offer, Amstutz, U., Schwab, M., Afd Pharmacoepi & Clinical Pharmacology, Barbarino, J., Schellens, J.H.M., Schwab, Matthias, Pharmacoepidemiology and Clinical Pharmacology, Linda M. Henricks, McLeod, H.L., Offer, S.M., Amstutz, Ursula, Swen, Jesse J., Jesse J. Swen, Henricks, L.M., Jan H.M. Schellens, Caudle, Kelly E, Klein, Teri E, Matthias Schwab, Barbarino, Julia, Henricks, Linda M, Robert B. Diasio, Swen, J.J., McLeod, Howard L, Howard L. McLeod, Offer, Steven M, Ursula Amstutz, Teri E. Klein, Diasio, Robert B   +35 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Clinical pharmacology in the UK, c. 1950–2000: influences and institutions

, 2008
The history of clinical pharmacology in the UK over the last half of the twentieth century is largely untold. Many important new drugs were developed and brought to market in the 1950s and 1960s ensuring the need for more systematic knowledge of drug ...
Reynolds, LA, Tansey, EM
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer [PDF]

, 2017
Wee1 is a protein kinase that regulates the G2checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 serine/threonine protein kinases that coordinate the progression through the cell cycle.
Geenen, Jill J., Schellens, Jan H M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Clinical pharmacology

Zdravniški Vestnik, 2006
Backgrounds: Clinical pharmacology has developed in the second half of 20th century and is now part of an undergraduate and postgraduate studies, being taught as a separate subject on most universities in developed countries.
Jože Drinovec
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement.

, 2020
Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of a drug.
Olagunju, Adeniyi, Momper, Jeremiah, Kiser, Jennifer J, Struble, Kimberly, Abrams, Elaine, Colbers, Angela, Best, Brookie M, Cressey, Tim R, Taylor, Graham, Waitt, Catriona, Capparelli, Edmund V, Bekker, Adrie, Mirochnick, Mark, Penazzato, Martina, Eke, Ahizechukwu C, Belew, Yodit, participants of the WHO-IMPAACT workshop on “Approaches to Optimize and Accelerate Pharmacokinetic Studies In Pregnant And Lactating Women”   +16 more
core   +1 more source

ANTACIDS CLINICAL PHARMACOLOGY

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2014
Antacids clinical pharmacology is represented according to the international classification of drugs ATC (anatomical-therapeutic-chemical). The article elucidates antacids indications and contraindications, administration details and side effects.
O. E. Tomina, M. I. Yabluchansky, O. Yu. Bychkova, O. O. Ivleva   +3 more
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