Results 231 to 240 of about 528,867 (309)

HIF-2α inhibitors in clear cell renal cell carcinoma: a clinical pharmacy perspective on lipid metabolism, therapeutic management, and resistance strategies. [PDF]

Front Med (Lausanne)
Chen D, Hua C.
europepmc   +1 more source

Clinical Pharmacy Education in a Dental Pharmacy

American Journal of Pharmaceutical Education, 1978
John A. Walker, Dennis K. Helling
openaire   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Artificial intelligence in clinical pharmacy-A systematic review of current scenario and future perspectives. [PDF]

Digit Health
Alqahtani SS, Menachery SJ, Alshahrani A, Albalkhi B, Alshayban D, Iqbal MZ.   +5 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

What Clinical Pharmacy Key Performance Indicator Processes of Care Were Patients Receiving across Canada in 2018? A National Patient Registry and Pooled Analysis. [PDF]

Can J Hosp Pharm
Carroccia A, Fernandes OA, Toombs K, Gorman SK, Spina SP, Semchuk WM, Meade A, Lowe D, Bayoud T, Shalansky S, Facca NM, Seto W, Bussières JF, Wong GG, Lui P, Slavik RS, Doucette D, Latariya G, Chant C.   +18 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Practice Guidelines for the Value Evaluation of Clinical Pharmacy Services (version 2). [PDF]

Front Public Health
Wu L, Lv Z, Chen M, Zheng X, Li L, Du S, Han L, Yin Q, Wang Y, Liu X, Li W, Huang X, Wang H, Yi X, Cui X, Chen Z, Wang Y, Hou Y, Zheng X, Lei Y, Gou M, Wu Y, Kang F, Cai F, Liang S, Yang Y, Li J, Bian Y.   +27 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Exploring current approaches towards patient prioritisation for clinical pharmacy services in UK mental health inpatient care. [PDF]

BMC Psychiatry
Alshaikhmubarak FQ, Keers RN, Brown P, Lewis PJ.   +3 more
europepmc   +1 more source