Results 171 to 180 of about 5,045,272 (312)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Clinical practice guideline for anterior segment dysgenesis. [PDF]

Jpn J Ophthalmol
Research on rare and intractable diseases, Health, Labour and Welfare Sciences Research Grants Clinical Practice Guideline Development Committee for Aniridia of the “Research group on establishing standardized diagnosis and treatment of Intractable corneal diseases”.   +2 more
europepmc   +1 more source

Reflective practice and clinical supervision. Developing good practice in GP appraisals [PDF]

, 2007
Launer, John
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Safety of Intravenous Edaravone in Clinical Practice. [PDF]

Muscle Nerve
Genge A, Apple S.
europepmc   +1 more source

Clinical research changing clinical practice

Injury, 2023
Peter, Augat, Hamish, Simpson, Volker, Alt   +2 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Practical Clinical Biochemistry [PDF]

Journal of Clinical Pathology, 1954
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Deprescribing in Older People: A Clinical Practice Guideline Summary. [PDF]

Med J Aust
Quek HW, Reus Perello X, Lee K, Abraham A, Adams LA, Almeida OP, Almutairi H, Armstrong B, Boase L, Breen J, Brown LJ, Caughey GE, Chan LW, Chen R, Chew E, Clark A, Comans T, Criddle D, Dārziņš P, Dawda P, Doust JA, Edwards S, Gowan J, Hart K, Hawthorne D, Heredia A, Hill AM, Jansen J, Kalisch Ellett L, Keen H, Kelty EA, Kerse NM, Kruger E, Kurrle SE, Lance H, Livori A, Livori R, LoGiudice DC, Mangoni AA, Marinucci A, McKay N, Mckendrick AM, McLachlan AJ, McGuire TM, Mearns S, Morgan M, Nabi S, Naganathan V, Newman E, Ng CACM, Osborne M, Parkin R, Polkinghorne KR, Pond CD, Potter K, Rigby D, Rowett D, Schipp A, Seda V, Seeto J, Shakib S, Shiu A, Stafford AC, Tan IJ, Tennant M, Teoh L, Tucker S, Watson JDG, Wellins D, Whitmore T, Etherton-Beer C, Page AT.   +71 more
europepmc   +1 more source