Results 191 to 200 of about 18,067,200 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The practice of clinical neurophysiology

Clinical Neurophysiology Practice, 2016
David Burke, Josep Valls-Solé, Susan T. Herman   +2 more
openaire   +3 more sources

Hodgkin lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow-up. [PDF]

Hemasphere
Eichenauer DA, André M, Borchmann P, Collins GP, Doherty I, Eich HT, Federico M, Fossa A, Hartmann S, Hutchings M, Illidge T, Kobe C, Plattel WJ, Specht L, Sureda A, Zaucha JM, Zijlstra JM, Aurer I.   +17 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

Clinical Infectious Diseases, 2016
P. Pappas, C. Kauffman, D. Andes, C. Clancy, K. Marr, L. Ostrosky-Zeichner, A. Reboli, M. Schuster, J. Vázquez, T. Walsh, T. Zaoutis, J. Sobel   +11 more
semanticscholar   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Perceptions of healthcare professionals in rheumatology on the use of prediction models in clinical practice. [PDF]

Rheumatol Adv Pract
Fadaei S, de Groot P, Kuin RRG, Spierings J, Herman A, Welsing PMJ, Verhoef LM.   +6 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Electroencephalography in clinical practice

Annals of Indian Academy of Neurology, 2018
openaire   +2 more sources

Remyelination therapies are achievable in clinical practice-No. [PDF]

Mult Scler
Shirani A, Stuve O.
europepmc   +1 more source