Results 181 to 190 of about 5,065,330 (358)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Remyelination therapies are achievable in clinical practice-Commentary. [PDF]

Mult Scler
Hedström AK.
europepmc   +1 more source

Clinical review of the identification and management of infants born to mothers with thyroid disease - is there a role for routine testing of maternal TRAB in the current practice? [PDF]

, 2015
Lucy Malpas
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Remyelination therapies are achievable in clinical practice-Yes. [PDF]

Mult Scler
Zuroff L, Cordano C, Green AJ.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Clinical Practice Guidelines for Peroral Cholangioscopy. [PDF]

J Hepatobiliary Pancreat Sci
Nagai K, Katanuma A, Ryozawa S, Okabe Y, Okano N, Kawashima H, Kawakami H, Kato H, Hayashi N, Irisawa A, Hatano E, Yasuda I, Igarashi Y, Itoi T.   +13 more
europepmc   +1 more source

European Society of Intensive Care Medicine (ESICM) 2025 clinical practice guideline on fluid therapy in adult critically ill patients: part 2—the volume of resuscitation fluids

Armand Mekontso Dessap, Fayez Alshamsi, Alessandro Belletti, Daniel De Backer, Anthony Delaney, Morten Hylander Møller, Ségolène Gendreau, Glenn Hernández, Flávia Ribeiro Machado, Mervyn Mer, Manuel Ignacio Monge García, Sheila Nainan Myatra, Zhiyong Peng, Anders Perner, Michael R. Pinsky, Sameer Sharif, Jean–Louis Teboul, Antoine Vieillard‐Baron, Waleed Alhazzani, the European Society of Intensive Care Medicine, Daniel De Backer, Morten Hylander Møller, Yaseen M. Arabi, Fayez Alshamsi, Emilie Belley-Cote, Andrea Carsetti, Alessandro Protti, Katia Donadello, Nicole Juffermans, Naomi Hammond, Jon Henrik Laake, Dawei Liu, Kathryn Maitland, Antonio Messina, Rob Mac Sweeney, Jean-Louis Vincent, Fernando Zampieri, Daniele Poole, Armand Mekontso-Dessap, Waleed Alhazzani, Fayez Alshamsi, Alessandro Belletti, Anthony Delaney, Glen Hernandez, Flavia R. Machado, Manuel Ignacio Monge García, Mervin Mer, Sheila Nainan Myatra, Michael R. Pinsky, Anders Perner, Zhiyong Peng, Sameer Sharif, Jean-Louis Teboul, Antoine Vieillard-Baron, Ségolène Gendreau, Marlies Osterman, Antonio Artigas Raventós, Ichai Carole, Maurizio Cecconi, Christina Jones, Xavier Monnet, Manu Malbrain, Marek Nalos, Zhiyong Peng, Carmen Pfortmueller, John Prowle, Otavio Ranzani, Manu Shankar-Hari Adrian Wong, Carl Thomas Anthon, Anders Granholm   +69 more
openalex   +2 more sources

P6246Utilization and effectiveness of alirocumab and evolocumab in improving lipid profile in routine clinical practice [PDF]

, 2017
Peter A. Noseworthy, Xiaoxi Yao, Nilay D. Shah   +2 more
openalex   +1 more source

Reflective practice and clinical supervision. Developing good practice in GP appraisals [PDF]

, 2007
Launer, John
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