Results 81 to 90 of about 15,514,333 (343)

Enrollment, retention, and strategies for including disadvantaged populations in randomized controlled trials: a systematic review protocol

Systematic Reviews, 2021
Background Many randomized controlled trials fail to reach their target sample size. When coupled with the omission and underrepresentation of disadvantaged groups in randomized controlled trials, many trials fail to obtain data that accurately ...
Abigail LaPlante, Renata W. Yen, Talia Isaacs, Joanna Crocker, Zsofia Demjen, Danielle Schubbe, Alice M. Kennedy, Jaclyn Engel, Nancy O’Brien, Carla Richters, Marie-Anne Durand   +10 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Assessment of knowledge, attitude, and practices of acute kidney injury incidence with co-administration of piperacillin/tazobactam and vancomycin among healthcare workers: A cross-sectional study

Saudi Pharmaceutical Journal, 2023
Background: No studies have identified a link between acute kidney injury (AKI) incidence due to the co-administration of vancomycin and piperacillin/tazobactam (VPT) and healthcare providers’ knowledge, attitudes, and practices.
Haytham A. Wali, Mohammed A. Alabdulwahed, Ghaida Y. Al-Hussain, Meaid A. Alabbad, Lojain H. Al-Khalaf, Sarah S. Alhumaidi, Khalid Alhussain, Sufyan M. Alomair, Abdulaziz S. Almulhim   +8 more
doaj  

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To provide updated recommendations about prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. METHODS PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs ...
N. Key, A. Khorana, N. Kuderer, Kari Bohlke, Agnes Y. Y. Lee, J. Arcelus, S. Wong, E. Balaban, C. Flowers, C. Francis, L. Gates, A. Kakkar, M. Levine, H. Liebman, M. Tempero, G. Lyman, A. Falanga   +16 more
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Clinical Hæmatology in Medical Practice [PDF]

, 1959

openalex   +2 more sources

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

Clinical Infectious Diseases, 2016
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to
P. Pappas, C. Kauffman, D. Andes, C. Clancy, K. Marr, L. Ostrosky-Zeichner, A. Reboli, M. Schuster, J. Vázquez, T. Walsh, T. Zaoutis, J. Sobel   +11 more
semanticscholar   +1 more source

On research in clinical practice

Perspectives in Clinical Research, 2010
Clinical research implies advancing current knowledge about health care by continually developing and testing new ideas about diseases, products, procedures, and strategies. Although this trait is inherent in human nature, it needs to be encouraged, nurtured, groomed, and channelized by creating a suitable atmosphere for it, providing the necessary ...
openaire   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Knowledge and attitude of human Mpox viral infection among pharmacy students in Jazan University: a web based cross-sectional study

Frontiers in Public Health
IntroductionSaudi Arabia has witnessed the first confirmed case of Mpox on July 14th, 2022. Currently, there is no approved medication for the treatment of this infection. Therefore, prevention of this infection is crucial.
Eman Merghani Ali, Eman Merghani Ali, Amani Khardali, Amani Khardali, Nawazish Alam, Nawazish Alam, Abdulkarim M. Meraya, Abdulkarim M. Meraya, Hilal A. Thaibah, Hilal A. Thaibah, Dalin A. Hassan, Mohamed Eltaib Elmobark, Alanood Aladwani, Alanood Aladwani, Anugeetha Thacheril Mohanan, Hanan A. Bakri, Zamzam O. Mashraqi, Areej Mousa Salhabi   +17 more
doaj   +1 more source