Results 101 to 110 of about 1,118,855 (308)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

The revised recommendation for administering vitamin C in septic patients: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020

Acute Medicine & Surgery, 2022
Guideline Committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Involving general practice trainees in clinical practice guideline adaptation

BMC Medical Education, 2018
Background It is unclear whether it is feasible to involve residents in guideline development or adaptation. We designed a multifaceted training program that combines training sessions, a handbook and a documentation tool to assist general practice (GP ...
Nicolas Delvaux, Martine Goossens, Paul Van Royen, Stijn Van de Velde, Robert Vanderstichele, Hanne Cloetens, Jan Vanschoenbeek, Bert Aertgeerts   +7 more
doaj   +1 more source

The Conundrum of Clinical Practice Guidelines

The Canadian Journal of Hospital Pharmacy, 2013
Clinical practice guidelines (CPGs) have been defined by the Institute of Medicine as “systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances”. The purported benefits of CPGs include improving patient outcomes, standardizing practice by ensuring a certain ...
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Decentralised Clinical Guidelines Modelling with Lightweight Coordination Calculus

, 2007
Background:Clinical protocols and guidelines have been considered as a major means to ensure that cost-effective services are provided at the point of care.
Lewis, Paul, Robertson, Dave, Hu, Bo, Dasmahapatra, Srinandan   +3 more
core  

Clinical Practice Guidelines

, 2015
Clinical Practice Guidelines (CPGs), have been a cornerstone of professional decision support in recent years and have come to play a pivotal role in routine clinical practice.
Beji, Nezihe Kizilkaya, Kurtcu, Asli
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Occupational health guidelines for the management of low back pain: an international comparison

, 2003
The enormous socioeconomic burden of low back pain emphasises the need for effective management of this problem, especially in an occupational context.
Koes, Bart; id_orcid, Staal, J B, Hlobil, H., van Tulder, MW; id_orcid, van Tulder, MW, Waddell, G., Staal, JB, Burton, A.K., van Mechelen, W, Koes, B. W., van Tulder, M.W., Koes, B.W., Staal, J. B., Staal, J.B., van Mechelen, W., Burton, A K, Van Tulder, M. W., Burton, AK, Koes, Bart, Burton, A. Kim, Koes, B W, Burton, A. K., van Tulder, M W, Hlobil, H, Waddell, G, Waddell, Gordon   +25 more
core   +1 more source