Results 81 to 90 of about 2,157,610 (303)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Association between quality of clinical practice guidelines and citations given to their references

, 2013
It has been suggested that bibliometric analysis of different document types may reveal new aspects of research performance. In medical research a number of study types play different roles in the research process and it has been shown, that the evidence-
Andersen, Jens Peter
core  

Changes in the 2017 Pediatric Hypertension Clinical Guidelines. [PDF]

, 2018
The clinical practice guidelines on diagnosis and management of high blood pressure in children and adolescents have been periodically modified and updated since the original publication in 1977.1 Since the last pediatric blood pressure guideline was ...
Falkner, Bonita
core   +1 more source

A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria: study protocol for a randomized controlled trial. [PDF]

, 2012
BACKGROUND: There is mounting evidence of poor adherence by health service personnel to clinical guidelines for malaria following a symptomatic diagnosis.
AK Rowe, B Nkrumah, B Uzochukwu, BSC Uzochukwu, BSC Uzochukwu, C Sismanidis, CIR Chandler, CIR Chandler, CK Murray, Cundill Bonnie, D Bell, D Mukanga, D Nonaka, DJ Kyabayinze, E Rolland, EN Shu, EN Shu, EN Shu, Enemuo Jane, Ezeoke Ogochukwu, H Hopkins, H Okabayashi, HA Williams, I Ayi, JM Kindermans, L Mangham, LH Moulton, M Hawkes, Mangham Lindsay J, MF Drummond, Nwala Emmanuel, O Onwujekwe, O Onwujekwe, O Onwujekwe, O Onwujekwe, Onwujekwe Obinna, P Chanda, RJ Hayes, S Shillcutt, TA Engli Okeke, Uchegbu Eloka, Uzochukwu Benjamin, V D'Acremont, VA Paul-Ebhohimhen, Virginia Wiseman, World Health Organization, World Health organization, World Health Organization, World Health Organization, World Health Organization, FIND, CDC, & TDR, Y Lubell, YB Cheung   +51 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Clinical Practice Guidelines

Florence Nightingale Journal of Nursing, 2019
Clinical Practice Guidelines (CPGs), have been a cornerstone of professional decision support in recent years and have come to play a pivotal role in routine clinical practice. CPGs arise from the evidence-based medicine movement, aiming at synthesizing
Aslı KURTÇU, Nezihe KIZILKAYA BEJİ
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Primary treatment of temporomandibular disorders: The Japanese Society for the temporomandibular joint evidence-based clinical practice guidelines, 2nd edition

Japanese Dental Science Review, 2013
In 2010 and 2012, the clinical practice guidelines committee of the Japanese Society for the temporomandibular joint published clinical guidelines for the primary treatment of temporomandibular disorders (TMDs) using the principles of evidence-based ...
Hidemichi Yuasa, Koji Kino, Eiro Kubota, Kenji Kakudo, Masashi Sugisaki, Akira Nishiyama, Yoshizo Matsuka, Nobumi Ogi, the Evidence-based Clinical Practice Guidelines Task Force   +8 more
doaj   +1 more source

What guidance are researchers given on how to present network meta-analyses to end-users such as policymakers and clinicians? A systematic review [PDF]

, 2014
© 2014 Sullivan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Abdelhamid, A Chaimani, A Cipriani, A Martin, A Nikolakopoulou, A Veroniki, B Hutton, D Chambers, D Hoaglin, D Moher, Doug Coyle, E Mills, EA Akl, F Song, G Salanti, G Salanti, G Salanti, George Wells, J Jansen, J Lavis, JP Jansen, L Trevena, MC Brouwers, N Daniels, N Hawkins, S Donegan, S Donegan, S Innvaer, SH Tan, SH Tan, Shannon M. Sullivan, SJ Pocock, Yu-Kang Tu   +32 more
core   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source