Results 181 to 190 of about 1,061,712 (264)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

International Clinical Practice Guidelines on Traditional Chinese Medicine Therapy for Dysmenorrhea: Development Protocol. [PDF]

JMIR Res Protoc
Zhang L, Liang X, Chen J, Du Y, Du H, Wang X.   +5 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Clinical Practice Guidelines in Dentistry

Journal of the California Dental Association
Elliot Abt, Christopher J. Smiley, Robert J. Weyant, Julie Frantsve-Hawley, Alonso Carrasco-Labra   +4 more
doaj   +1 more source

Clinical practice guidelines for the prevention and management of postoperative nausea and vomiting (2025 edition). [PDF]

J Anesth Transl Med
Hu J, Wang Z, Ma B, Wang T, Wang E, Yu W, Chinese Society of Anesthesiology Working Group on Clinical Practice Guidelines for the Prevention and Management of Postoperative Nausea and Vomiting (2025 Edition).   +6 more
europepmc   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Evidence-based clinical practice guidelines for metabolic dysfunction-associated steatotic liver disease (MASLD) 2026. [PDF]

J Gastroenterol
Akuta N, Kogiso T, Ikejima K, Otsuka M, Kawaguchi T, Kawanaka M, Takahashi H, Tamaki N, Nakagawa H, Hikita H, Fujii H, Yamaguchi K, Yoneda M, Kon K, Uchiyama A, Seko Y, Sakane S, Shigefuku R, Fujiwara N, Iwaki M, Kobayashi T, Adachi T, Takeuchi Y, Tsutsumi T, Nakano D, Shibayama K, Urata N, Miyaaki H, Kuroda H, Koseki M, Sone H, Matsubayashi Y, Kakisaka K, Takai A, Notsumata K, Seike M, Takei Y, Takeyama Y, Eguchi S, Watanabe S, Isomoto H, Yotsuyanagi H, Itoi T, Takehara T, Mochida S.   +44 more
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Clinical practice guidelines for the management of differences of sex development in Japan. [PDF]

Endocr J
Ishii T, Kashimada K, Kawai M, Itonaga T, Iwasa T, Utsunomiya A, Ozaki K, Kawamura K, Kanno J, Koh J, Kojima Y, Sasaki S, Sato H, Shiraishi K, Naiki Y, Nishiyama M, Hamajima T, Fujisawa Y, Makita N, Matsui K, Yanai T, Horikawa R, Ogata T.   +22 more
europepmc   +2 more sources