Results 81 to 90 of about 3,299,699 (357)

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Changes in the 2017 Pediatric Hypertension Clinical Guidelines. [PDF]

, 2018
The clinical practice guidelines on diagnosis and management of high blood pressure in children and adolescents have been periodically modified and updated since the original publication in 1977.1 Since the last pediatric blood pressure guideline was ...
Falkner, Bonita
core   +1 more source

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
A Donner, AJ Bellg, AJ Engers, Australian Acute Musculoskeletal Pain Guidelines Group (AAMPGG), B McGuirk, BF Walker, BF Walker, BS Frankel, C Bombardier, C Bombardier, D Di Iorio, D Mortimer, Denise A O'Connor, DG Altman, DG Altman, DK Freeborn, Duncan Mortimer, DW King, DW King, EM Hay, FB Hu, G Waddell, GM Fitzmaurice, H Britt, H Schers, J Francis, J Mollison, J Zhang, Jeremy M Grimshaw, Jill Francis, JJ Yallop, JM Grimshaw, JM Neuhaus, JM Schectman, Joanne E McKenzie, M Campbell, M Eccles, M Roland, M Roland, M Von Korff, MK Campbell, MR Robling, N Klar, Neil Spike, NJ Horton, OC Ukoumunne, P Dey, P Little, P Oakeshott, PB Bishop, Peter M Kent, Peter Schattner, PJ Diggle, PM Kent, R Buchbinder, R Buchbinder, R Buchbinder, R Buchbinder, R Grol, Rachelle Buchbinder, S Hakkennes, S Hollis, S Kerry, S Michie, Sally E Green, Simon D French, SJ Pocock, SJ Senn, SR Heritier, Susan Michie, SZ George, T Permutt, TS Carey, V Gonzalez-Urzelai, W Hardeman   +74 more
core   +4 more sources

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

I.S.Mu.L.T. Achilles Tendon Ruptures Guidelines [PDF]

, 2018
This work provides easily accessible guidelines for the diagnosis, treatment and rehabilitation of Achilles tendon ruptures. These guidelines could be considered as recommendations for good clinical practice developed through a process of systematic ...
Alessio Giai Via,, Alfonso Maria Forte,, Angelo De Carli,, Anna, Collina, Antonio, Vadal\ue0, Asmaa, Mahmoud, Bernardi, Gabriele, Bernardo, Innocenti, Biagio, Moretti, Biz, Carlo, Calogero, Foti, Carlotta, Galeone, Clelia, Rugiero, Daniela, Buonocore, Domenico, Lupariello, Edoardo, Gaj, Eleonora, Piccirilli, Emanuela, Marsilio, Fantoni, Ilaria, Finotti, Paolo, Francesca, Veronesi, Francesco Di Pietto,, Frizziero, Antonio, Gamberini, Jacopo, Gasparini, Monica, Imma Di Lanno,, Johnny, Padulo, Leonardo, Pellicciari, Luca, Perazzo, Luigi Di Lorenzo,, Manuela, Verri, Marcello, Zappia, Maria Chiara Vulpiani,, Mario, Vetrano, Matteo, Baldassarri, Maurizia, Dossena, Michela, Bossa, Milena, Fini, Nicola, Maffulli, Oliva, Francesco, Pasquale, Farsetti, Pietro, Picerno, Roberto, Buda, Ruggieri, Pietro, Simone, Natali, Umberto, Tarantino, Vincenzo De Luna,, Vito, Chianca   +47 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

COMORBIDITIES IN PRACTICE. CLINICAL GUIDELINES

Кардиоваскулярная терапия и профилактика, 2017
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R. G. Oganov, I. N. Denisov, V. I. Simanenkov, I. G. Bakulin, N. V. Bakulina, S. A. Boldueva, O. N Barbarash, N. P Garganeeva, V. L Doshchitsin, O. M. Drapkina, E. N. Dudinskaya, Yu. V. Kotovskaya, A. M. Lila, M. N. Mamedov, B. U. Mardanov, O. N. Miller, M. M. Petrova, Yu. M. Pozdnyakov, N. K. Runikhina, S. A. Sayganov, A. V. Tarasov, O. N. Tkacheva, A. M. Urinsky, S. A. Shalnova   +23 more
doaj   +1 more source

Inconsistent evidence: Analysis of six national guidelines for vaginal birth after cesarean section [PDF]

, 2010
Background: Guidelines are increasingly used to direct clinical practice, with the expectation that they improve clinical outcomes and minimize health care expenditure. Several national guidelines for vaginal birth after cesarean section (VBAC) have been
Foureur, M, Homer, C, Nicholl, M, Ryan, CL   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source