Results 81 to 90 of about 1,341,814 (306)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Does protocol heterogeneity in active surveillance influence clinical outcomes? Insights from a multicenter prostate cancer cohort [PDF]

Investigative and Clinical Urology
Purpose: Active surveillance (AS) is recommended for men with low-risk prostate cancer, but institutional variability exists in eligibility criteria, confirmatory biopsy policies, and monitoring schedules.
Young Hwii Ko, Jae Hyun Ryu, Yun Beom Kim, Teak Jun Shin, Byung Hoon Kim   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Clinical Profile and Management Outcomes of Krait and Cobra Envenomation: A 3-year Observational Study from Rural Maharashtra, India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Snake bite envenomation remains a critical public health concern in rural India, with the Indian Cobra (Naja naja) and Common Krait (Bungarus caeruleus) responsible for a significant proportion of morbidity and mortality.
Sadanand D. Raut, Sandesh S. Raut, Sachin Shivnitwar   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Outpatient paracentesis for Ovarian Hyperstimulation Syndrome: STOP-OHSS feasibility study and RCT Synopsis

Health Technology Assessment
Background Ovarian hyperstimulation syndrome is a potentially serious complication of fertility treatments. Standard care often involves monitoring, then hospitalisation for severe cases.
Mostafa Metwally, Katie Ridsdale, Clare Pye, Munya Dimairo, Amy Barr, Ying Cheong, Lauren Desoysa, Sarah Drabble, Andrew Drakeley, Isaac Evbuomwan, Laura Flight, Jennifer Hannington, Jane Hughes, Anju Keetharuth, Amanda Loban, Elizabeth Lumley, Raj Mathur, Kirsty McKendrick, Cara Mooney, Alicia O’Cathain, Eloise Pyper, Rich Simmonds, Liz Taylor, Jessica Wright, Siqi Wu, Tracey Young, David White   +26 more
doaj   +1 more source

CT Examinations for COVID-19: A Systematic Review of Protocols, Radiation Dose, and Numbers Needed to Diagnose and Predict

대한영상의학회지, 2021
Purpose Although chest CT has been discussed as a first-line test for coronavirus disease 2019 (COVID-19), little research has explored the implications of CT exposure in the population.
Jong Hyuk Lee, Hyunsook Hong, Hyungjin Kim, Chang Hyun Lee, Jin Mo Goo, Soon Ho Yoon   +5 more
doaj   +1 more source

Clinical management protocols: the bedside answer to clinical practice guidelines.

, 1998
TOPIC: Clinical Management Protocols for trauma patients. PURPOSE: The goals and process for developing and implementing Clinical Management Protocols are presented.
Pasquale, Michael D, MD, FACS, FCCM, Fuss, Mae Ann, MSN, RN, CCRN   +1 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comprehensive Analysis of Different Subtypes of Oxylipins to Determine a LC–MS/MS Approach in Clinical Research

Metabolites
Background/Objectives: Different oxylipin subtypes have unique biological properties, requiring effective analytical protocols. However, establishing a complete pathway detection protocol for comprehensive oxylipin analysis is challenging.
Yurou Zhao, Zhengyu Fang, Zeyu Li, Yizhe Liu, Yang Bai, Xiaoqing Wang, Hongjun Yang, Na Guo   +7 more
doaj   +1 more source