Results 11 to 20 of about 10,048,421 (237)

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum

Plants, 2021
Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed.
Katja Kramberger, Saša Kenig, Zala Jenko Pražnikar, Nina Kočevar Glavač, Darja Barlič-Maganja   +4 more
doaj   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Optimal search strategies for identifying sound clinical prediction studies in EMBASE [PDF]

, 2005
BACKGROUND: Clinical prediction guides assist clinicians by pointing to specific elements of the patient's clinical presentation that should be considered when forming a diagnosis, prognosis or judgment regarding treatment outcome.
A Laupacis, AG Randolph, AR Jadad, BJ Ingui, BT Walsh, CE Adams, FA McAlister, Jennifer L Holland, JF Steiner, JH Wasson, JI Emparanza, JW Ely, LM Bachmann, LM Bachmann, Nancy L Wilczynski, NL Wilczynski, NL Wilczynski, NL Wilczynski, PS Wells, R Brian Haynes, RB Haynes, RB Haynes, RJ Watson, SS Wong, T McGinn, TG McGinn   +25 more
core   +3 more sources

Implementierung und Erprobung eines Lernziel-basierten Evaluationssystems im Studium der Humanmedizin [Piloting an outcome-based programme evaluation tool in undergraduate medical education]

GMS Zeitschrift für Medizinische Ausbildung, 2012
[english] Aims: Different approaches to performance-oriented allocation of resources according to teaching quality are currently being discussed within German medical schools.
Raupach, Tobias, Schiekirka, Sarah, Münscher, Christian, Beißbarth, Tim, Himmel, Wolfgang, Burckhardt, Gerhard, Pukrop, Tobias   +6 more
doaj   +1 more source

Current Trends in Gelatin-Based Drug Delivery Systems

Pharmaceutics, 2023
Gelatin is a highly versatile natural polymer, which is widely used in healthcare-related sectors due to its advantageous properties, such as biocompatibility, biodegradability, low-cost, and the availability of exposed chemical groups. In the biomedical
Francesca Milano, Annalia Masi, Marta Madaghiele, Alessandro Sannino, Luca Salvatore, Nunzia Gallo   +5 more
doaj   +1 more source

Clinical study FOURIER [PDF]

Vnitřní lékařství, 2017
A new group of hypolipidemic substances, i.e. PCSK9 protein inhibitors, is now coming into use in clinical practice, to what extent a high residual cardiovascular risk remains also in patients treated with statins. The FOURIER study (Further cardiovascular OUtcomes Research with PCSK9 Inhibition subjects with Elevated Risk) is the first "event" study ...
openaire   +2 more sources

The Efficacy of Selected Desensitizing OTC Products: A Systematic Review. [PDF]

, 2014
Licensed by the Creative Commons Attribution LicenseObjectives. The aim of the present study was to review the published literature in order to identify relevant studies for inclusion and to determine whether there was any evidence on the clinical ...
Gillam, DG, Hill, R, Talioti, E
core   +4 more sources

Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review

Biomolecules, 2022
Neurodegenerative disorders including Parkinson’s disease (PD), Huntington’s disease (HD) and the most frequent, Alzheimer’s disease (AD), represent one of the most urgent medical needs worldwide.
Jana Klose, Carola Griehl, Steffen Roßner, Stephan Schilling   +3 more
doaj   +1 more source

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT. [PDF]

, 2018
FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML.
Bharate, Jaideep B, Ding, Lucky, Frett, Brendan, Lakkaniga, Naga Rajiv, Li, Hong-Yu, McConnell, Nicholas, Naresh, Gunaganti, Shah, Neil P, Zhang, Lingtian   +8 more
core   +2 more sources