Results 31 to 40 of about 9,880,911 (259)

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Painful Diabetic Neuropathy: Sex-Specific Mechanisms and Differences from Animal Models to Clinical Outcomes

Cells
Diabetes is a chronic and progressive disease associated with high blood glucose levels. Several co-morbidities arise from diabetes, the most common and severe one is diabetic neuropathy whose symptoms also include pain hypersensitivity. Currently, there
Emma Merlin, Chiara Salio, Francesco Ferrini   +2 more
doaj   +1 more source

Note From the Editor [PDF]

, 2014
Background and AimsTo review published studies on the effectiveness of combining cognitive-behavioural therapy (CBT) and motivational interviewing (MI) to treat comorbid clinical and subclinical alcohol use disorder (AUD) and major depression (MDD) and ...
Andersson, Gerhard, Berking, Matthias, Cuijpers, Pim, de Wit, Jessica, Hunter, Sarah B., Riper, Heleen   +5 more
core   +3 more sources

The role of weaning in brace treatment for developmental dysplasia of the hip: time to define best practice?

Bone & Joint Open
Aims: In infants aged under six months with developmental dysplasia of the hip (DDH), the use of a removable brace is considered the gold-standard treatment. However, considerable variation exists for brace removal after ‘successful’ treatment.
Joanna Craven, Ioan Davies, Daniel C Perry   +2 more
doaj   +1 more source

Performance of mesenchymal cell-scaffold constructs in human oral reconstructive surgery: a systematic review [PDF]

, 2016
Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few ...
ANNIBALI, Susanna, Cristalli, Maria Paola, LA MONACA, Gerardo, MARINI, ROBERTA, Patini, Romeo, PRANNO, NICOLA   +5 more
core   +1 more source

Anti-inflammatory Effects of Olive Oil and Its Components. Prospects of Application in the Treatment of Inflammatory Bowel Diseases

Педиатрическая фармакология
In recent years, there has been a significant increase in the prevalence of inflammatory bowel diseases. Despite the significant progress made in the instrumental diagnosis of this group of diseases, their treatment in most cases remains formalized ...
Anatoly I. Khavkin, Andrew V. Nalyotov, Maria A. Matsynina   +2 more
doaj   +1 more source

Animal mesenchymal stem cell research in cartilage regenerative medicine – a review

Veterinary Quarterly, 2019
Healing of articular cartilage is a major clinical challenge as it also lacks a direct vasculature and nerves, and carries a limited number of resident chondrocytes that do not proliferate easily.
Mudasir Bashir Gugjoo, Amarpal, Mujeeb-Ur Rehman Fazili, Mohmmad Abrar Gayas, Raja Aijaz Ahmad, Kuldeep Dhama   +5 more
doaj   +1 more source

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT. [PDF]

, 2018
FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML.
Bharate, Jaideep B, Ding, Lucky, Frett, Brendan, Lakkaniga, Naga Rajiv, Li, Hong-Yu, McConnell, Nicholas, Naresh, Gunaganti, Shah, Neil P, Zhang, Lingtian   +8 more
core   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Metabolic therapy in cardiology from the perspective of evidence-based medicine

Фундаментальная и клиническая медицина, 2021
Over the past few decades, various applications of the metabolic drugs have been extensively tested. Most of them affect oxygen-dependent processes, improving cellular metabolism and increasing tissue resistance to hypoxia and ischemia.
V. I. Kostin, O. A. Shangina, V. G. Shelikhov   +2 more
doaj   +1 more source