Results 11 to 20 of about 60,673,388 (296)

BCPT 2023 policy for experimental and clinical studies

open access: yesBasic & Clinical Pharmacology & Toxicology, 2023
The manuscript is an updated version of the previously published "BCPT policy for experimental and clinical studies" from 2021.
P. Tveden-Nyborg   +4 more
semanticscholar   +1 more source

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

open access: yesSignal Transduction and Targeted Therapy, 2023
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major risk factors. Based on epigenetic data, HNC is remarkably heterogeneous,
Qing-Fang Li   +4 more
semanticscholar   +1 more source

Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts

open access: yesFrontiers in Genetics, 2022
The same genetic variant found in different individuals can cause a range of diverse phenotypes, from no discernible clinical phenotype to severe disease, even among related individuals.
R. Kingdom, C. Wright
semanticscholar   +1 more source

GLP-1 receptor agonists: an updated review of head-to-head clinical studies

open access: yesTherapeutic Advances in Endocrinology and Metabolism, 2021
Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are attractive options for the treatment of type 2 diabetes (T2D) because they effectively lower A1C and weight while having a low risk of hypoglycemia. Some also have documented cardiovascular benefit.
Jennifer M. Trujillo   +2 more
semanticscholar   +1 more source

A Review of the Effects of Collagen Treatment in Clinical Studies

open access: yesPolymers, 2021
Collagen, an abundant extracellular matrix protein, has been found to have a lot of pharmaceuticals, medicine, food, and cosmetics applications. Increased knowledge of collagen sources, extraction techniques, structure, and properties in the last decades
Hsiu-Fen Wang
semanticscholar   +1 more source

The growth of siRNA-based therapeutics: updated clinical studies

open access: yesBiochemical Pharmacology, 2021
More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market.
M. Zhang   +4 more
semanticscholar   +1 more source

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

open access: yesBioScience Trends, 2020
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China.
Jian-Jun Gao, Zhenxue Tian, Xu Yang
semanticscholar   +1 more source

Osteosarcopenia: A Narrative Review on Clinical Studies

open access: yesInternational Journal of Molecular Sciences, 2022
Osteosarcopenia (OS) is defined by the concurrent presence of osteopenia/osteoporosis and sarcopenia. The pathogenesis and etiology of OS involve genetic, biochemical, mechanical, and lifestyle factors. Moreover, an inadequate nutritional status, such as
A. Polito   +3 more
semanticscholar   +1 more source

Accuracy of digital implant impressions in clinical studies: A systematic review.

open access: yesClinical Oral Implants Research, 2022
OBJECTIVES The use of intraoral scanners (IOSs) for digital implant impressions in daily clinical practice is increasing. However, no structured literature review on the accuracy of digital implant impressions in clinical studies has been described to ...
A. Schmidt, B. Wöstmann, M. Schlenz
semanticscholar   +1 more source

Honey Bee Products: Preclinical and Clinical Studies of Their Anti-inflammatory and Immunomodulatory Properties

open access: yesFrontiers in Nutrition, 2022
Inflammation is a defense process triggered when the body faces assaults from pathogens, toxic substances, microbial infections, or when tissue is damaged.
H. El-Seedi   +12 more
semanticscholar   +1 more source

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