The development of new highly effective medications with acceptable safety profile targeted at the treatment of multiple sclerosis (MS) is one of the most important problems of modern neurology.
Marina V. Votintseva +2 more
doaj +1 more source
Aim Since GH stimulates lipolysis in vivo after a 2‐hr lag phase, we studied whether this involves GH signaling and gene expression in adipose tissue (AT).
Katrine L. Høyer +10 more
doaj +1 more source
Clinical Studies Target Fewer Complications, Better Outcomes for Vascular Surgery [PDF]
Two studies at the Jefferson Vascular Center (JVC) are assessing innovative methods to reduce risk of complications — and increase positive outcomes — for vascular surgery patients. Here, Paul DiMuzio, MD, FACS, William M. Measey Professor of Surgery and
core +1 more source
Remdesivir for the Treatment of COVID-19: A Systematic Review of the Literature [PDF]
In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is
Aly, Besma +9 more
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Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]
Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
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The difficult task of predicting the costs of community-based mental health care. A comprehensive case register study. [PDF]
Previous studies have attempted to forecast the costs of mental health care, using clinical and individual variables; the inclusion of ecological measures could improve the knowledge of predictors of psychiatric service utilisation and costs to support ...
Amaddeo, F. +6 more
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Correction to: Risk Factors for Progression from Subclinical to Clinical Phase of Psoriatic Arthritis: A Case–Control Study [PDF]
Yiyi Wang +11 more
openalex +1 more source
Current regulatory approaches for accessing potential COVID-19 therapies
This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID-19 potential therapies either with off-label use, compassionate use, emergency use or for clinical trials.
Vesa Halimi +6 more
doaj +1 more source
Current regulatory requirements for clinical trials of viral vaccines
Scientific relevance. In recent years, the development of various vaccines based on novel platforms has underscored the significance of updating regulatory requirements for vaccines.
A. A. Soldatov +3 more
doaj +1 more source
Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes Sense for Brain Injury. [PDF]
Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home ...
Gurkoff, Gene G +4 more
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