Results 1 to 10 of about 12,286,608 (353)

Clinical case study

Community Eye Health Journal, 2013
With increasing international travel it is important that ophthalmologists become familiar with the various ocular presentations of infectious diseases, which untreated can cause serious morbidity and mortality.
Irfan Jeeva, Aditi Das, Andy Cassels-Brown   +2 more
doaj   +2 more sources

Cytoreductive Surgery (CRS) Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Platinum-Sensitive Recurrence Epithelial Ovarian Cancer With HRR Mutation: A Phase III Randomized Clinical Trial

Technology in Cancer Research & Treatment, 2022
Background : Epithelial ovarian cancer (EOC) remains the leading cause of gynecologic cancer death worldwide due to the high recurrence rate. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an alternative ...
Yuwen Qi MD, Yaxing Zhang MD, Yuying Shi MD, Shijie Yao MM, Mengyuan Dai MD, Hongbing Cai MD   +5 more
doaj   +1 more source

Alternative Splicing: A New Therapeutic Target for Ovarian Cancer

Technology in Cancer Research & Treatment, 2022
Background: Increasing evidences have shown that abnormal alternative splicing (AS) events are closely related to the prognosis of various tumors. However, the role of AS in ovarian cancer (OV) is poorly understood.
Shijie Yao MM, Cheng Yuan MD, Yuying Shi MD, Yuwen Qi MD, Radhakrishnan Sridha MD, Mengyuan Dai MD, Hongbing Cai MD   +6 more
doaj   +1 more source

Clinical trials challenges - impact of the new clinical trial regulation on the conduct of clinical trials [PDF]

Vojnosanitetski Pregled, 2022
nema
Mugoša Snežana, Glusica Anja
doaj   +1 more source

RNAi in Clinical Studies [PDF]

Current Medicinal Chemistry, 2013
RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
P, Kubowicz, D, Żelaszczyk, E, Pękala
openaire   +2 more sources

Electro-acupuncture for irritable bowel syndrome patients: study protocol for a single-blinded randomized sham-controlled clinical trial

Trials, 2021
Background Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders in clinical practice. IBS diagnosis is based on symptoms defined by abdominal pain or discomfort associated with defecation or changes in bowel ...
Linda L. D. Zhong, Tsz Fung Lam, Wei Yang, Ya Zheng, Zipan Lyu, Zhaoxiang Bian   +5 more
doaj   +1 more source

Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial

Trials, 2022
Background The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects.
Martin Coenen, Ulrike Bingel, Matthias Zunhammer, Maria Soledad Berdaguer, Christine Fuhrmann, Rolf Fimmers, Jens Rengelshausen, Gunther Hartmann, Manfred Schedlowski, Christoph Coch   +9 more
doaj   +1 more source

Efficacy of Negative Pressure Wound Therapy Followed by Delayed Primary Closure for Abdominal Wounds in Patients with Lower Gastrointestinal Perforations: Multicenter Prospective Study

Journal of the Anus, Rectum and Colon, 2020
Objectives: The efficacy of negative pressure wound therapy (NPWT) and its application to severely contaminated wounds sustained during surgery remain to be established. Here, we evaluated the efficacy of utilizing NPWT until delayed primary closure (DPC)
Hirofumi Ota, Katsuki Danno, Katsuya Ohta, Tae Matsumura, Takamichi Komori, Shu Okamura, Miho Okano, Atsuhiro Ogawa, Hiroshi Tamagawa, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Riichiro Nezu, Yuichiro Doki, Hidetoshi Eguchi   +15 more
doaj   +1 more source

Transcriptome of GH-producing pituitary neuroendocrine tumours and models are significantly affected by somatostatin analogues

Cancer Cell International, 2023
Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect.
Rihards Saksis, Olesja Rogoza, Helvijs Niedra, Kaspars Megnis, Ilona Mandrika, Inga Balcere, Liva Steina, Janis Stukens, Austra Breiksa, Jurijs Nazarovs, Jelizaveta Sokolovska, Ilze Konrade, Raitis Peculis, Vita Rovite   +13 more
doaj   +1 more source

An Attempt to Replicate Randomized Trials of Diabetes Treatments Using a Japanese Administrative Claims and Health Checkup Database: A Feasibility Study

Drugs - Real World Outcomes, 2023
Background Use of real-world evidence (RWE) has been limited for evaluating effectiveness because of the lack of confidence in its reliability. Examining whether a rigorously designed observational study using real-world data (RWD) can reproduce the ...
Ryozo Wakabayashi, Takahiro Hirano, Tadashi Koga, Ryohei Kuwatsuru   +3 more
doaj   +1 more source