Results 101 to 110 of about 12,286,608 (353)

Lightweight Data Integration Frameworks for Clinical Research [PDF]

, 2012
Research data from a single clinical study is often spread across multiple applications and systems. We present a reusable, lightweight, secure framework for automatically integrating and querying study data from heterogeneous sources in order to answer ...
Brinkley, James, Hertzenberg, Xenia, Shaker, Ronald   +2 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Influence of Cavity Lining on the 3-Year Clinical Outcome of Posterior Composite Restorations: A Randomized Controlled Clinical Trial

Dentistry Journal
The purpose of this randomized, split-mouth-designed controlled and single-blinded clinical study was to evaluate the 3-year clinical performance of Class I and Class II resin composite restorations placed with or without cavity lining with a flowable ...
Anh Duc Nguyen, Natalie Pütz, Mary Michaelis, Kerstin Bitter, Christian Ralf Gernhardt   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial [PDF]

, 2020
Mehdi Ghahremani, Mohammad Fathi, Nilofar Massoudi, Sasan Tavana, Kamal Fani, Navid Nooraee, Nasser Malekpour Alamdari, Sara Besharat, Arash Najafi Abrandabadi, Ali Pirsalehi, Mohammad Ali Khabiri Khatiri, Maryam Amini Pouya, Samira Rajaei, Ali Dabbagh   +13 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

Food Science and Human Wellness
Ganoderma lucidum, one of the most well-known edible fungi, is believed to be very benef icial for longevity and vitality. A long usage history suggests that G. lucidum has various clinical therapeutic effects.
Sijia Wu, Siyuan Zhang, Bo Peng, Dechao Tan, Mingyue Wu, Jinchao Wei, Yitao Wang, Hua Luo   +7 more
doaj   +1 more source

Innovative Strategies of Reprogramming Immune System Cells by Targeting CRISPR/Cas9-Based Genome-Editing Tools: A New Era of Cancer Management

International Journal of Nanomedicine, 2023
Khaled S Allemailem,1 Mohammed A Alsahli,1 Ahmad Almatroudi,1 Faris Alrumaihi,1 Waleed Al Abdulmonem,2 Amira A Moawad,3 Wanian M Alwanian,1 Nahlah Makki Almansour,4 Arshad Husain Rahmani,1 Amjad Ali Khan5 1Department of Medical Laboratories, College of ...
Allemailem KS, Alsahli MA, Almatroudi A, Alrumaihi F, Al Abdulmonem W, Moawad AA, Alwanian WM, Almansour NM, Rahmani AH, Khan AA   +9 more
doaj  

GPla Polymorphisms Are Associated with Outcomes in Patients at High Cardiovascular Risk

Frontiers in Cardiovascular Medicine, 2017
BackgroundPlatelet membrane glycoprotein receptors mediate thrombus formation. GP Ia/IIa is an essential platelet integrin receptor. Single-nucleotide polymorphisms (SNPs) of the GP Ia/IIa gene alter GP Ia/IIa expression; however, their influence on ...
Dominik Rath, Elke Schaeffeler, Elke Schaeffeler, Stefan Winter, Stefan Winter, Semjon Levertov, Karin Müller, Michal Droppa, Fabian Stimpfle, Harald F. Langer, Meinrad Gawaz, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Tobias Geisler   +15 more
doaj   +1 more source

Response by Steinberg et al to Letter Regarding Article, “Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2A Study” [PDF]

, 2016
Gary K. Steinberg, Douglas Kondziolka, Damien Bates   +2 more
openalex   +1 more source