Results 81 to 90 of about 2,077,481 (282)

Stem Cell Antigen CD34 In Native And Engineered Form Alter Its Binding Ability To Stromal Cells And Ligands: A Classical Example Of Clinical Benefits Of Therapeutic Genetic Engineering Of Stem Cells In Transplantation [PDF]

, 2010
CD34 is a highly glycosylated surface-expressed sialomucin and, because it is present on hematopoietic stem cells (HSCs), has demonstrated immense clinical utility in their enumeration in aphaeresis products, immunoaffinity purification for ...
Gurudutta Gangenahalli, Neeraj Kumar Satija, Pallavi Gupta, Rajendra Prasad Tripathi, Vimal Kumar Singh, Yogesh Kumar Verma   +5 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Predictors of Technical and Clinical Success of ERCP in Patients with Biliary Obstruction: A Study from a Tertiary Referral Center in Indonesia

Acta Medica Indonesiana
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a primary therapeutic modality for managing malignant and benign biliary obstruction.
Tony Darmadi, Achmad Fauzi, Dadang Makmun, Hamzah Shatri, Djoa Theadora Rebecca Santoso   +4 more
doaj   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Challenging Social Cognition Models of Adherence:Cycles of Discourse, Historical Bodies, and Interactional Order [PDF]

, 2015
Attempts to model individual beliefs as a means of predicting how people follow clinical advice have dominated adherence research, but with limited success.
Alexander F., Atkinson J. M., Bowker G., Charlotte Salter, Charmaz K., Christensen A. J., Cornwell J., Department of Health, Dunbar F., Duranti A., Fairclough N., Fiona Poland, Goffman E., Hymes D., Jamie Murdoch, Jane Cross, Maimonides M., McLeod C., Mishler E. G., Osler W., Peyrot M., Salter H. H., Scollon R., Silverman D., Sontag S.   +24 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Endoscopic Self-Expandable Metallic Stent Insertion without Fluoroscopic Guidance Is Feasible and Safe for Acute Colonic Obstruction Caused by Colorectal Cancer

Gastroenterology Research and Practice, 2020
Aims. Endoscopic self-expandable metallic stent (SEMS) insertion for acute colonic obstruction caused by colorectal cancer (CRC) is always performed under fluoroscopic guidance.
Yadong Feng, Qian Yu, Ming Li, Wei Xu, Ye Zhu, Yang Liu, Ruihua Shi   +6 more
doaj   +1 more source

Splenectomy and Thymectomy in Human Renal Homotransplantation [PDF]

, 1963
Five patients with terminal renal failure have been treated with renal homografts. Total body irradiation and cytotoxic drugs were used to prevent rejection.
Marchioro, TL, Starzl, TE, Talmage, DW, Waddell, WR   +3 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Correlation of mechanical factors and gallbladder pain [PDF]

, 2008
Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of ...
Bird, N.C., Chin, S.B., Hill, N.A., Johnson, A.G., Li, W.G., Luo, X.Y., Smythe, A.   +6 more
core   +3 more sources