Results 61 to 70 of about 7,995,840 (309)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Not Available

, 2020
Scientific Pig rearing-A success story of pig growers of GoaScientific Pig rearing-A success story of pig growers of GoaNot ...
Sanjay K Udharwar, Chetan Kumar H.B., Naik S., Chakurkar E.B., Gokuldas PP   +4 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comparative Analysis of Vital and Nonvital Pulp Therapy Outcomes in Pediatric Endodontics

Journal of Pharmacy and Bioallied Sciences
Background: Pulp therapy in pediatric endodontics is crucial for maintaining primary teeth until natural exfoliation. Vital pulp therapy (VPT) and non-vital pulp therapy (NVPT) are commonly employed based on pulp status. Materials and Methods: A total of
R Venkatasubramanian, B. K Ramnarayan, Krishnanand P. Satelur, J Avinash, M Hemanth, Vidya M. Annegowda   +5 more
doaj   +1 more source

Serum Albumin Level Adjusted Progesterone Level on the Trigger Day is Not a Significant Predictor of Clinical Pregnancy

Gynecology Obstetrics & Reproductive Medicine, 2018
Objective: We aimed to assess the effect of serum albumin level adjusted progesterone levels on the trigger day on clinical pregnancy rate in ICSI cycles.
Cigdem Yayla Abide, Enis Ozkaya, Semra Kayatas Eser, Belgin Devranoğlu, Bulent Emre Bilgic, Tayfun Kutlu   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Principles of Decision Making on the Prescription of Medicines. What else Do You Need to Know when Interpreting the Results of Clinical Trials?

Педиатрическая фармакология, 2018
What can become the basis for the decision making when prescribing a medicine, choosing one instead of another? Words and their combinations ‘randomised controlled study’, ‘double blind’, ‘meta-analysis’, ‘relevant difference’ have a kind of hypnotic ...
Yuliya A. Petrovskaya, Ludmila M. Ogorodova, Fedor I. Petrovskiy   +2 more
doaj   +1 more source

International Student Success Office, University of Regina

, 2008
4 p.
University of Regina, International Student Success Office.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source