Results 91 to 100 of about 1,136,022 (274)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Evaluating the Field Practicum Experience in Social Work Fieldwork Programs Using an Online Survey Approach: Student and Supervisor Responses

open access: yesSocial Work and Society, 2018
A key issue for busy education managers is how to design evaluative research to obtain quality and reliable data to enhance fieldwork programme development.
Margaret Pack
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Medical students’ perception of supervision in MedUniVienna’s structured internal medicine and surgery clerkship program: Subject-specific differences and clerkship sequence effects

open access: yesGMS Journal for Medical Education
Background: Clerkships for supervised learning of clinical skills are part of modern medical curricula. The availability of clerkship placements in clinics and the provision of competent supervision are essential for effective work-based learning.
Hofhansl, Angelika   +6 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Nursing Student's Perceptions of the Clinical Learning Environment, Supervision and Nurse Teacher: A Cross-Sectional Study

open access: yesJournal of Nursology
Objective: This study aimed to determine nursing students' perceptions of the clinical learning environment, supervision and nurse teacher, and its affecting factors.
Anita Karaca   +2 more
doaj   +1 more source

Homework in Cognitive Behavioral Supervision: Theoretical Background and Clinical Application

open access: gold, 2022
Ján Praško   +9 more
openalex   +2 more sources

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