Results 71 to 80 of about 755,685 (219)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Key determinants for lowering the risk of joint replacement in weight-bearing joints: a population-based cohort study

Arthroplasty
Background Hip and knee replacement (arthroplasty) is used to treat advanced joint disease by reducing pain and restoring joint function. This study aimed to identify determinants associated with a lower risk of joint replacement (JR).
Aminu Suleiman, Mojtaba Lotfaliany, Lana J. Williams, Amanda L. Stuart, Richard Page, Stephen Gill, Anusha P. Budehal, Julie A. Pasco   +7 more
doaj   +1 more source

Parental mental health during preconception years in association with offspring attention deficit hyperactivity disorder (ADHD): a systematic review protocol

BMJ Open
Introduction Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric condition prevalent in both children and adults. With growing awareness of the importance of the preconception period in health, it is essential to understand whether ...
Julie A Pasco, Lana J Williams, Natalie K Hyde, Shae E Quirk, Ditty Ann Johns   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Maternal Metformin Exposure Induces Gut Microbial Shifts in Non-Diabetic Dams and Sex-Stratified Changes in Mouse Offspring

Biomolecules
Beyond being one of the most widely prescribed medications for type 2 diabetes, metformin has been increasingly used during pregnancy for gestational diabetes and polyendocrine metabolic ovarian syndrome.
Dat Da Ly, Kate Phuong-Nguyen, Trang T. T. Truong, Bryony A. McNeill, Kathryn Aston-Mourney, Leni R. Rivera   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Paternal Influences on Offspring Bone, Muscle and Growth in Childhood and Adulthood: A Systematic Review

Reproductive, Female and Child Health
Objective There is a growing body of evidence examining the paternal origins of health and disease. This review aimed to systematically search extant literature regarding the relationship between paternal lifestyle and health exposures during early life,
Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Sarah M. Hosking, Natalie K. Hyde   +4 more
doaj   +1 more source

Research progress on the fanconi anemia signaling pathway in non-obstructive azoospermia

Frontiers in Endocrinology
Non-obstructive azoospermia (NOA) is a disease characterized by spermatogenesis failure and comprises phenotypes such as hypospermatogenesis, mature arrest, and Sertoli cell-only syndrome.
Haohui Xu, Haohui Xu, Yixin Zhang, Yixin Zhang, Caiqin Wang, Caiqin Wang, Zhuoyan Fu, Zhuoyan Fu, Jing Lv, Jing Lv, Yufang Yang, Yufang Yang, Zihan Zhang, Zihan Zhang, Yuanmin Qi, Yuanmin Qi, Kai Meng, Jinxiang Yuan, Xiaomei Wang   +18 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Paternal Influences on Offspring Bone, Muscle and Body Composition at Birth: A Systematic Review

Reproductive, Female and Child Health
Objectives There is growing evidence for the paternal origins of health and disease. This review aimed to systematically search the literature examining relationships between paternal exposures during early life, peri/conception or pregnancy, and ...
Mia A. Percival, Kara B. Anderson, Julie A. Pasco, Sarah M. Hosking, Natalie K. Hyde   +4 more
doaj   +1 more source