Results 131 to 140 of about 1,604,147 (168)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Improving transparency in clinical trial reporting. [PDF]

PLoS Med
Farrell A, PLOS Medicine Editors.
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Digital Psychological Intervention for Inflammatory Rheumatic Diseases: A Pilot Randomized Clinical Trial.

JAMA Netw Open
Knitza J, Kraus J, Krusche M, Haase I, Klemm P, Hueber AJ, Pfeil A, Drott U, Kuhn S, Klein JP.   +9 more
europepmc   +1 more source

An anti-TSLP monoclonal antibody for uncontrolled CRSwNP: the DUBHE randomized clinical trial. [PDF]

Nat Commun
Xian M, Lan F, Yan B, Shen S, Liu S, Wan L, Song X, Jiang L, Jiang Y, Xue J, Chen J, Su L, Ye J, Yang Y, Fang H, Tan G, Zhang Q, Qu S, Wei X, Luo X, Xu Y, Yu S, Xiao Z, Liu F, Li Q, Zhang Y, Xie Y, Wang L, Yang G, Yan H, Zhao G, Chen B, Wang C, Zhang L.   +33 more
europepmc   +1 more source

Acupuncture for Chronic Low Back Pain in Older Adults: A Randomized Clinical Trial.

JAMA Netw Open
DeBar LL, Wellman RD, Justice M, Avins AL, Beyrouty M, Eng CM, Herman PM, Nielsen A, Pressman A, Stone KL, Teets RY, Cook AJ.   +11 more
europepmc   +1 more source

A Hybrid Chatbot to Promote Pneumococcal Vaccination Among Older Adults: A Randomized Clinical Trial.

JAMA Netw Open
Wang Z, Chen S, Poon J, Han SC, Ye D, Yu FY, Fang Y, Ni Z, Wong MCS, Mo PKH.   +9 more
europepmc   +1 more source

Poststroke Cardiorespiratory Exercise for Brain Volume and Cognition: A Randomized Clinical Trial.

JAMA Netw Open
Brodtmann A, Churilov L, Adkins K, Haibe R, Tucker S, Khlif MS, Werden E, McCambridge LJE, Telfer R, Kramer S, Cardoso BR, Pase M, Launder N, Egorova-Brumley N, Hung SH, Burrell LM, Williams G, Thijs V, Bernhardt J, Johnson L, Hayward KS, PISCES-ZODIAC Investigators.   +21 more
europepmc   +1 more source

Biological vs Synthetic Mesh in Laparoendoscopic Inguinal Hernia Repair: The BIOLAP Randomized Clinical Trial.

JAMA Surg
Seefeldt CS, Knievel J, Deeb M, Hoedt NT, Rudroff C, Essen R, Antoine D, Kaiser GM, Jacobi CA, Gross-Weege W, Gänsler W, Lammers BJ, Bonk C, Hildebrandt F, Carus T, Meyer M, Bebobru M, Krökel A, Dornbusch J, Schneider M, Cerasani N, Stechemesser B, Lefering R, Bulian DR, Ströhlein MA, Rieger A, Lange J, Meyer-Zillekens JS, Eisenberger CF, Heiss MM.   +29 more
europepmc   +1 more source