Results 141 to 150 of about 2,211,903 (315)

Industry sponsored medical device clinical trials

, 2009
The total number of industry sponsored medical device trials registered with the US trial register between October 2005 and June 2009 was 1,017.
Karlberg, JPE
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial

Drug Design, Development and Therapy
Cheng Cui,1– 3 Jixiang Zhu,1,2 Zhiping Liu,1– 3 Jingyao Liu,1,2 Xiaomin Huang,1,2 Yi Liu,4 Jingqiu Hu,4 Lingli Zhang,4 Xue Zhang,4 Yila Sha,4 Dongyang Liu,1– 3 Haiyan Li1– 3 1Drug Clinical Trial Center, Department of Pharmacy, Peking University Third ...
Cui C, Zhu J, Liu Z, Liu J, Huang X, Liu Y, Hu J, Zhang L, Zhang X, Sha Y, Liu D, Li H   +11 more
doaj  

Recent landscape and trends for industry‐sponsored pediatric clinical trials in China from 2013 to 2022

Pediatric Investigation
Importance Pediatric medication is a challenging issue globally. Promoting trials of medications for children and implementing measures to encourage innovation for addressing unmet medical and health needs are important.
Chang Liu, Yi Liu, Ling Ou, Yuenan Qi, Jianmin Zhang   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Hawthorne Effect: a randomised, controlled trial

, 2007
Background: The 'Hawthorne Effect' may be an important factor affecting the generalisability of clinical research to routine practice, but has been little studied.
Griffin, M, Iliffe Steve, McCarney Rob, Robbert van Haselen, Griffin Mark, Iliffe, S, Fisher Peter, Warner James, Fisher, P, van Haselen Robbert, Warner, J, Mark Griffin, McCarney, R, James Warner, van Haselen, R, Peter Fisher, Steve Iliffe, Rob McCarney   +17 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a systematic review with meta-analysis and trial sequential analysis

BMJ Open
Objectives To assess the beneficial and harmful effects of regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes.Design Systematic review of randomised clinical trials with meta-analysis and trial ...
Janus Christian Jakobsen, Sophie Juul, Tiago Jeronimo Dos Santos, Pascal Faltermeier, Johanne Juul Petersen, Christina Dam Bjerregaard Sillassen, Caroline Barkholt Kamp   +6 more
doaj   +1 more source

National Center of Excellence for Clinical Trials and Research at National Taiwan University Hospital

, 2011
The clinical research of National Taiwan university Hospital (NTUH) focuses on developing new treatments for endemic diseases in Taiwan. The major approach is through the clinical trials focusing on molecular targeted therapy.
林家齊;楊志新;鄭安理;陳榮楷;何弘能, LIN, CHIA-CHI;YANG, CHIH-HSIN;CHENG, ANN-LII;CHAN, WING-KAI;HO, HONG-NERNG   +1 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source