Results 161 to 170 of about 9,816,425 (315)
Prescreening clinical trial volunteers using an online personality questionnaire
, 2018 Fiona Patrick,1 Allan H Young1,2 Steven CR Williams,2,3 Adam M Perkins1,2 1Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK; 2National Institute for Health Research ...
Williams SCR +3 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Industry sponsored oncology clinical trials
, 2009 The US clinical trial register data was analysed to characterise industry and partially non-industry sponsored oncology clinical trials. The analysis found 2,248 trials with 45,882 study sites and 420,378 study subjects for industry-sponsored oncology ...
Yao, TJ, Karlberg, JPE, Yau, HKC
core
LEGAL ASPECTS OF CLINICAL TRIALS INVOLVING UNDER-AGE SUBJECTS IN RUSSIA
Педиатрическая фармакология, 2010 The article focuses on a complicated, no less pressing issue of conducting clinical trials in pediatrics. When vulnerable groups of patients are involved as subjects in clinical trials, specific ethical issues inevitably arise.
S.S. Zavidova, A.A. Tolpanova
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A trial-blazer in clinical research
Founded in 2005, Gallipoli Medical Research (GMR) is a leading independent medical research institute located in Greenslopes, Brisbane, Queensland. GMR strives to enrich and restore lives through pioneering medical research that transcends the laboratory
Elliott, Suzanne +3 more
core +1 more source
Improving the clinical trial landscape for Parkinson syndromes in Germany. [PDF]
J Neural Transm (Vienna)Höglinger G +18 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source