Results 151 to 160 of about 13,113,839 (405)

MIRACIL. CLINICAL TRIAL ON PATIENTS INFECTED WITH SCHISTOSOMA HAEMATOBIUM AND S. MANSONI [PDF]

, 1949
David Blair, Frank Hawking, C. V. Meeser, Whitney Ross   +3 more
openalex   +1 more source

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

International Journal of Antimicrobial Agents, 2020
P. Gautret, J. Lagier, P. Parola, V. Hoang, L. Meddeb, M. Mailhe, B. Doudier, J. Courjon, V. Giordanengo, V. E. Vieira, H. Tissot Dupont, S. Honoré, P. Colson, E. Chabrière, B. La Scola, J. Rolain, P. Brouqui, D. Raoult   +17 more
semanticscholar   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Sequential Allocation and Balancing Prognostic Factors in a Psychiatric Clinical Trial [PDF]

, 2008
In controlled clinical trials, each of several prognostic factors should be balanced across the trial arms. Traditional restricted randomization may be proved inadequate especially with small sample sizes.
Basilio B. Pereira, Carlos A. B. Pereira, Euripedes C. Miguel, Juliana B. Diniz, Victor Fossaluza   +4 more
core   +1 more source

Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial.

JAMA Internal Medicine, 2015
IMPORTANCE Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia.
C. Valls-Pedret, A. Sala-Vila, M. Serra‐Mir, D. Corella, R. de la Torre, M. Martínez-González, E. Martinez-Lapiscina, M. Fitó, A. Pérez-Heras, J. Salas‐Salvadó, R. Estruch, E. Ros   +11 more
semanticscholar   +1 more source

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

A Clinical Trial of the Epinephrine-Mecholyl Test in a Mixed Group of Psychiatric Patients [PDF]

, 1958
George Mathew Ramapuram, E. V. Metcalfe, J. A. F. Stevenson, Glyn Hobbs   +3 more
openalex   +1 more source

Influenza antivirals currently in late‐phase clinical trial

Influenza and Other Respiratory Viruses, 2017
Influenza antiviral drugs are important for the control of influenza, most specifically for the treatment of influenza patients with severe disease following infection with a seasonal influenza virus, a newly emerging influenza strain, or in the event of
Paulina Koszalka, Danielle Tilmanis, A. Hurt   +2 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Exploring the Generalization of Cancer Clinical Trial Eligibility Classifiers Across Diseases [PDF]

arXiv
Clinical trials are pivotal in medical research, and NLP can enhance their success, with application in recruitment. This study aims to evaluate the generalizability of eligibility classification across a broad spectrum of clinical trials. Starting with phase 3 cancer trials, annotated with seven eligibility exclusions, then to determine how well ...
arxiv