Results 41 to 50 of about 60,343,578 (236)

Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Efficacy and Mechanism Evaluation
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually all critical ...
Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin   +74 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Communication about children's clinical trials as observed and experienced: qualitative study of parents and practitioners. [PDF]

, 2011
Recruiting children to clinical trials is perceived to be challenging. To identify ways to optimise recruitment and its conduct, we compared how parents and practitioners described their experiences of recruitment to clinical ...
Shilling, V, Smyth, RL, Bridget Young (128749), Helen Hickey (166297), Paula R. Williamson, Bridget Young, Helen Hickey, Emma Sowden (214406), Valerie Shilling (4460977), Paula R Williamson, Shilling Valerie, Beresford Michael W., Valerie Shilling, Young, B, Rosalind L Smyth, Michael W Beresford, Hickey Helen, Rosalind L Smyth (16234277), Michael W Beresford (9964186), Beresford, MW, Sowden, E, Williamson Paula R., Michael W. Beresford, Emma Sowden, Smyth Rosalind L., Young Bridget, Williamson, PR, Hickey, H, Rosalind L. Smyth, Sowden Emma, Paula R Williamson (11606900)   +30 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

What can we learn from clinical trials of anticonvulsant drugs in epilepsy?

, 2002
Any physician who intends to utilize the available antiepileptic drugs (AEDs) judiciously, cannot do so without being well versed on their pharmacological properties and the large body of evidence that is continuously accumulating on their relative ...
What Can We Learn From Clinical Trials Of Anticonvulsant Drugs In Epilepsy?, PERUCCA, EMILIO   +1 more
core   +1 more source

Outcome Based Subgroup Analysis: A Neglected Concern. [PDF]

, 2009
A subgroup of clinical trial subjects identified by baseline characteristics is a proper subgroup while a subgroup determined by post randomization events or measures is an improper subgroup.
Fagerland, Morten W, Hirji, K.F, Fagerland, M.W., Hirji, Karim F, Fagerland Morten W, Hirji Karim F, Fagerland, M.W, Hirji, K.F.   +7 more
core   +1 more source

Informative Censoring in CDK4/6 Inhibitor Adjuvant Therapy for Early Breast Cancer: A Sensitivity Analysis of Invasive Disease-Free Survival in the monarchE Trial

Epidemiology, Biostatistics and Public Health
INTRODUCTION The estimation of survival curves and hazard functions relies on the assumption of non-informative censoring—that is, the censoring time for an individual provides no further information about that person’s likelihood of survival at a ...
Federico Merlo , Fabio Conforti , Vincenzo Bagnardi   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Rethinking Anticoagulation in Kidney Disease and Kidney Transplantation

Panorama of Emergency Medicine
Background A clinical dilemma exists in patients with CKD, ESKD, and after kidney transplantation, as they face concurrent risks of both thromboembolic and hemorrhagic complications. Objective To review the literature on anticoagulant treatments in CKD,
Antoine Zgheib
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source