Results 41 to 50 of about 82,153 (256)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Emerging multitarget tyrosine kinase inhibitors in the treatment of neuroendocrine neoplasms [PDF]

, 2018
In the last few years, the therapeutic approach for neuroendocrine neoplasms (NENs) has changed dramatically following the approval of several novel targeted treatments.
Florio, Tullio, Francesco Ferraù, Annamaria Colao, Faggiano, Antongiulio, Elda Kara, Kara, Elda, Tullio Florio, Colao, Annamaria A L, Federica Grillo, Ferraù, Francesco, Giuseppe Fanciulli, Colao, Annamaria, Grillo, Federica, Fanciulli, Giuseppe, Antongiulio Faggiano, _ _   +15 more
core   +1 more source

Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Efficacy and Mechanism Evaluation
Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually all critical ...
Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin   +74 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

SPOT: Sequential Predictive Modeling of Clinical Trial Outcome with Meta-Learning

, 2023
Clinical trials are essential to drug development but time-consuming, costly, and prone to failure. Accurate trial outcome prediction based on historical trial data promises better trial investment decisions and more trial success. Existing trial outcome
Sun, Jimeng, Wang, Zifeng, Xiao, Cao
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Bayesian Adaptive Designs and Versatile Software Platform For Early Phase Clinical Trials

, 2020
This research is dedicated to improve the efficiency of Bayesian adaptive designs for early phase clinical trials. Phase I clinical trials can be conducted using algorithm-based (also known as rule-based), model-based, or model-assisted designs. Numerous
Zhou, Yanhong
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Informative Censoring in CDK4/6 Inhibitor Adjuvant Therapy for Early Breast Cancer: A Sensitivity Analysis of Invasive Disease-Free Survival in the monarchE Trial

Epidemiology, Biostatistics and Public Health
INTRODUCTION The estimation of survival curves and hazard functions relies on the assumption of non-informative censoring—that is, the censoring time for an individual provides no further information about that person’s likelihood of survival at a ...
Federico Merlo , Fabio Conforti , Vincenzo Bagnardi   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source