Results 181 to 190 of about 55,609,055 (315)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Global inequities in representation of low-income and middle-income countries in vaccine clinical trials: protocol for a systematic review and meta-epidemiological analysis. [PDF]

BMJ Open
Ramalan M, Yusuf I, Mathew M, Bako I, Imam MU, Musa B.   +5 more
europepmc   +1 more source

Design and Endpoints of Clinical Trials in Hepatocellular Carcinoma

, 2008
The design of clinical trials in hepatocellular carcinoma (HCC) is complex because many patients have concurrent liver disease, which can confound the assessment of clinical benefit. There is an urgent need for high-quality trials in this disease.
Josep M. Llovet, Barnett S. Kramer, Gregory J. Gores, Adrian M. Di Bisceglie, Myron Schwartz, Michael Lotze, Jayant Talwalkar, Jordi Bruix, Andrew X. Zhu, Morris Sherman, LENCIONI, RICCARDO ANTONIO, for the Panel of Experts in HCC Design Clinical Trials   +11 more
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Publication Rate and Discontinuation Percentage of Registered Trials Involving Rotator Cuff Pathology. [PDF]

Orthop J Sports Med
Miquel J, Verdaguer-Figuerola A, Vinas-Noguera M, Salomó-Domènech M, Lizundia A, Torrens C.   +5 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Partnering with patients and the public in the clinical trials ecosystem: a decade of lessons learned and shared. [PDF]

BMJ Open
Richards DP, Fink C, Granieri M, Kobow K, Lane T, Lillie D, Mitchell K, Munro C, Smith M, Walz M, Marlin S.   +10 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Commentary on Getting it right before transplantation: example of a stem cell model with regenerative potential for the CNS, Perspective article by Viero et al.

Frontiers in Cell and Developmental Biology, 2014
Lidia eCova, Dan eLindholm, Dan eLindholm   +2 more
doaj   +1 more source

Editorial: Exercise in aquatic environment and health. [PDF]

Front Sports Act Living
Farinha C, Santos C, Santos H, Martinez P, Ricardo Y, Serrano J.   +5 more
europepmc   +1 more source