Results 231 to 240 of about 612,154 (364)

Blockchain integration for rare disease clinical trials. [PDF]

Ann Med Surg (Lond)
Riaz U, Talha M, Ali U, Hassan M, Mahato RK.   +4 more
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Potential differences between real-life and randomized controlled trial populations in chronic myeloid leukemia. [PDF]

Ann Hematol
Horňák T, Žáčková D, Mayer J.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

A framework for Surgical Quality Assurance (SQA) in randomized controlled trials in gastrointestinal surgery: an international Delphi consensus study. [PDF]

EClinicalMedicine
van der Aa DC, Henckens SPG, Bonjer HJ, Tuynman JB, Besselink MG, Blencowe NS, Hanna GB, van Berge Henegouwen MI, Markar SR, Gisbertz SS, DELPHI-study group.   +10 more
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

International use of social cognition assessments: Commentary on Ziermans et al. [PDF]

Schizophr Res Cogn
Green MF, Nuechterlein KH.
europepmc   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study.

BMJ
Chaboud L, Janiaud P, Hirt J, Hemkens LG.   +3 more
europepmc   +1 more source

Basket trials in rare diseases: a systematic review of current practices, methodological challenges, and future directions. [PDF]

Orphanet J Rare Dis
Khazen W, Corriol-Rohou S, Evangelista T, Valent A, Abbas S, Nissan X, Mejat A.   +6 more
europepmc   +1 more source