Results 251 to 260 of about 624,126 (316)

Investigating the impact of problematic evidence on clinical practice guidelines and associated patient outcomes (VITALITY Study II): protocol. [PDF]

BMJ Open
Xu C, Furuya Kanamori L, Cao H, Wang X, Loke YK, Li S, Wen T, Fan S, Gu Z, Stone JC, Lin L, Yisha Z, Cristea IA, Du L, Clark J, Qin Z, Song Y, Zeng L, Fan Z, Golder S, Chu H, Murad MH, Lin H, Mol BW, Vohra S, Doi SA.   +25 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

EULAR-OMERACT consensus-based scoring system for synovitis 10 years later: a validated tool for routine care and clinical trials. [PDF]

RMD Open
Terslev L, D'Agostino MA.
europepmc   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Exploratory analyses of clinical trials - what can they tell us and what are the potential pitfalls? [PDF]

Nat Commun
europepmc   +1 more source

Editorial: Cellular senescence in aging-related diseases: mechanisms and therapeutic targets. [PDF]

Front Cell Dev Biol
Zhou J, Wang H, Zhu F.
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Synthesis and Standardization of Outcomes in Severe Malaria Treatment Trials: Protocol for the Development of a Core Outcome Set (the COSSMaT Study).

JMIR Res Protoc
Asamoah GD, Love SB, Gibb DM, Maitland K, George EC.   +4 more
europepmc   +1 more source

Inflammation-neurotrophin synergy of Xiao-yao-san-type botanical drug formulations in depressive disorders: a qualitative synthesis of recent human studies with taxonomic and compositional characterisation. [PDF]

Front Pharmacol
Han L, Liang Q.
europepmc   +1 more source