Results 81 to 90 of about 41,551 (186)

The Changing Landscape of Heart Failure Drug Clinical Trials in China, 2013–2023

Drug Design, Development and Therapy
Wenjie Zhang,1,2,* Yinming Zhang,3,* Jiawei Tang,4,* Xuejiao Wang,1 Chao Meng,1,2 Ji Wu,1 Jun Li1 1Department of Cardiology, Guang’Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, People’s Republic of China ...
Zhang W, Zhang Y, Tang J, Wang X, Meng C, Wu J, Li J   +6 more
doaj  

RESEARCH ETHICS COMMITTEES (RECs) AND MONITORING OF BIOMEDICAL RESEARCH IN PAKISTAN

Khyber Medical University Journal, 2013
Global health is facing enormous challenges and medical research is the only way to cope with these challenges. Worldwide, extensive clinical research is being conducted in all fields of medicineto resolve the health related issues through best available
Akhtar Sherin
doaj  

Undertaking Studies Within A Trial to evaluate recruitment and retention strategies for randomised controlled trials: lessons learnt from the PROMETHEUS research programme

Health Technology Assessment
Background Randomised controlled trials (‘trials’) are susceptible to poor participant recruitment and retention. Studies Within A Trial are the strongest methods for testing the effectiveness of strategies to improve recruitment and retention.
Adwoa Parker, Catherine Arundel, Laura Clark, Elizabeth Coleman, Laura Doherty, Catherine Elizabeth Hewitt, David Beard, Peter Bower, Cindy Cooper, Lucy Culliford, Declan Devane, Richard Emsley, Sandra Eldridge, Sandra Galvin, Katie Gillies, Alan Montgomery, Christopher J Sutton, Shaun Treweek, David J Torgerson   +18 more
doaj   +1 more source

THE ETHICAL STARTUP?

Voices in Bioethics
Photo ID 345549 © Jonathan Mulkey | Dreamstime.com Abstract Emerging DNA marketplace startups aim to empower individuals with greater control and potential profit-sharing over their genetic data, but they face ethical tensions in navigating ...
Alexis Walker
doaj   +1 more source

Safety and data monitoring committees for clinical trials [PDF]

Clinical Cardiology, 1995
openaire   +2 more sources

Monitoring of large randomised clinical trials: a new approach with Bayesian methods.

, 2001
BACKGROUND: In judging whether or not to continue enrolling patients into a randomised clinical trial, most data-monitoring and ethics committees (DMECs) rely on the p value for the difference in effect between the study groups.
Parmar, MK, Douglas G Altman, Griffiths, GO, Parmar, Mahesh K.B., Emmanuel van der Scheuren, Spiegelhalter, DJ, CHART steering committee, Souhami, R. L., Griffiths, Gareth O., Altman, DG, Altman, Douglas G., Spiegelhalter, D., van der Scheuren, Emmanuel, Spiegelhalter, David J., Mahesh KB Parmar, David J Spiegelhalter, Souhami, RL, Souhami, Robert L., Gareth O Griffiths, van der Scheuren, E, van der Scheuren, E., Altman, D. G., Parmar, MKB, van der Scheueren, Emmanuel, Robert L Souhami, Parmar, M.   +25 more
core   +1 more source

Serious adverse event reporting in investigator-initiated clinical trials

, 2016
Reporting adverse events (AEs) and serious AEs (SAEs) are practical steps to ensure safety for volunteers and patients in medical research involving medications, treatments and devices.
Zalcberg, J., Wallace, S., Zeps, Nikolajs, Myles, P.   +3 more
core   +1 more source

Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation

Health Technology Assessment
Background Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is used to prevent acute gout flares in patients with gout.
Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald   +18 more
doaj   +1 more source

Premature stopping of LEIA-HF: protecting trial participants while preserving clinical knowledge. [PDF]

ESC Heart Fail
Grand J, Olesen ASO, Jakobsen JC.
europepmc   +1 more source

Is Australia well equipped to deal with future clinical trials ?

, 2016
The French Biotrial tragedy highlighted the potential for healthy volunteers to suffer tragic injuries in clinical trials and the need for clear and effective regulatory oversight.
Lisa Eckstein (14735866), Donald Chalmers (14733439)   +1 more
core