Results 181 to 190 of about 4,045,482 (205)

Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report. [PDF]

Mol Pharm
Tannergren C, Arora S, Babiskin A, Borges L, Chatterjee P, Cheng YH, Dallmann A, Govada A, Heimbach T, Hingle M, Kollipara S, Kotzagiorgis E, Lindahl A, Mackie C, Malamatari M, Mitra A, Moody R, Pepin X, Polli J, Raines K, Rullo G, Sanghavi M, Savkur R, Singh R, Sjögren E, Suarez-Sharp S, Thomas S, Veerasingham S, Wei K, Wu F, Xu Y, Yoon M, Rege B.   +32 more
europepmc   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for <i>Codonopsis</i>-Derived Triterpenoid Saponins. [PDF]

Drug Des Devel Ther
Zhang X, Yang C, Wang P, Yang P, Liu S, Liu S, Yang X.   +6 more
europepmc   +1 more source

Multifunctional Nanomaterials for Precision Diagnostics and Drug Delivery: AI-Assisted Biosensing, Barrier-Directed Transport, Stimuli-Responsive Release, and Theranostic Integration. [PDF]

Molecules
Bellucci S.
europepmc   +1 more source

Overcoming Gastric Barriers for Oral Peptide Delivery: QbD-Based Development of Sodium Caprate-Enabled Tirzepatide Tablets. [PDF]

Pharmaceutics
Im S, Lee JY, Kim JE.
europepmc   +1 more source

Toward oral nanomaterial-based drug delivery systems for hepatocellular carcinoma therapy: evidence mapping, route-specific validation, and translational challenges. [PDF]

Front Pharmacol
Fu Y, Ge Y, Yi S, Peng Q, Jiang H, Zhou J.   +5 more
europepmc   +1 more source

Nanomaterial-enabled delivery of plant-derived bioactive metabolites for diabetic retinopathy: from evidence appraisal to preclinical translation. [PDF]

Front Pharmacol
Zhao D, Wang C, Jiang Z, Xu Y, Xia Y, Zhang P, Ye H.   +6 more
europepmc   +1 more source

Detecting clinically relevant EEG anomalies using discrete wavelet transforms

, 2005
Jahankhani, P., Revett, K., Kodogiannis, V.   +2 more
core  

Physiologically Based Biopharmaceutics Model of Vildagliptin Modified Release (MR) Tablets to Predict In Vivo Performance and Establish Clinically Relevant Dissolution Specifications

AAPS PharmSciTech, 2022
The objective of the study was to predict pharmacokinetic (PK) and pharmacodynamic (PD) parameters of matrix-based modified release (MR) drug product of vildagliptin. Physiologically based biopharmaceutics modeling (PBBM) was developed using GastroPlus™ based on the available data including immediate-release (IR) drug product of vildagliptin.
Muzaffaruddin Ahmed, Madny, Pandurang, Deshpande, Venkat, Tumuluri, Parag, Borde, Ramachandra, Sangana   +4 more
exaly   +4 more sources