Results 101 to 110 of about 12,385,464 (249)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

theoriegestuurde evaluatie periode 2002-2011 [PDF]

, 2011
In 2002 the Dutch government initiated a national policy to tackle domestic violence. This report considers how that policy has taken shape since then and what results have been seen.
Plaisier, J., Lindenberg, R., Jongebreur, W.   +2 more
core   +1 more source

Comparison of ocular residual astigmatism between children with clinically significant and non-significant astigmatism

BMC Ophthalmology
Purpose To compare the difference of ocular residual astigmatism (ORA) in children with clinically significant astigmatism and non-significant astigmatism. Methods This is a cross-sectional study. Participants were divided into the clinically significant
Jian Lin, Dexiang An, Jun Zhu, Dongmei Yan   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Evaluatie Recidiveregeling voor ernstige verkeersdelicten [PDF]

, 2015
Sinds 1 juni 2011 krijgen bestuurders die voor een tweede maal worden veroordeeld voor het rijden onder invloed van alcohol te maken met de recidiveregeling. Hun rijbewijs wordt van rechtswege ongeldig, zonder verdere tussenkomst van de rechter.
Goedvolk, M., Walberg, A., Doumen, M.
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Age- and Risk-Based Stratification in Dyspepsia: Redefining Endoscopic Thresholds for Clinically Significant and Malignant Findings

Clinics and Practice
Background: Dyspepsia is a common indication for gastroscopy, yet its diagnostic yield for malignancy and other clinically significant findings (CSF) remains low. Improved risk stratification is therefore essential to guide endoscopic referral.
Oren Gal, Dorin Nicola, Amir Mari, Randa Natour, Noor Fanadka, Ahlam Bsoul, Ahmad Mahamid, Rawi Hazzan, Fadi Abu Baker   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

LIVER ABLATION IN CIRRHOTIC PATIENTS WITH CLINICALLY SIGNIFICANT PORTAL HYPERTENSION: CURRENT EVIDENCE, CHALLENGES, AND EMERGING ROLE OF ELASTOGRAPHY

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale
Liver ablation is a cornerstone therapy for early-stage hepatocellular carcinoma (HCC), offering a curative-intent option for patients ineligible for resection or transplantation. However, the presence of clinically significant portal hypertension (CSPH)
Angela PELTEC, Artur BODRUG, Inga BODRUG, Roman BODRUG   +3 more
doaj   +1 more source