Results 81 to 90 of about 12,385,464 (249)

A risk‐organised model for clinically significant prostate cancer early detection

BJUI Compass, 2023
Juan Morote, Ángel Borque‐Fernando, Marina Triquell, José M. Abascal, Pol Servian, Jacques Planas, Olga Mendez, Luis M. Esteban, Enrique Tilla   +8 more
doaj   +1 more source

Establishing Clinically Significant Outcomes After Meniscal Allograft Transplantation

Orthopaedic Journal of Sports Medicine, 2019
Background: Traditionally, the primary outcome in meniscal allograft transplantation (MAT) has been long-term survivorship; however, short-term clinically significant outcomes are necessary to fully evaluate patient improvement after surgery. Purpose: To
Joseph N. Liu MD, Anirudh K. Gowd BS, Michael L. Redondo MS, David R. Christian BS, Brandon C. Cabarcas BS, Adam B. Yanke MD, PhD, Brian J. Cole MD, MBA   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Acceptance and Commitment Therapy for depression following psychosis: an examination of clinically significant change [PDF]

, 2015
Depression following psychosis is common and can impact negatively on individuals’ quality of life. This study conducted post-hoc analyses on 14 participants with psychosis from a larger randomised controlled trial who presented with clinically important
McTaggart, J., Rattrie, L., Rattrie, Lucy, White, Ross, McTaggart, Jacqueline, Gumley, A.I., McConville, D., Mitchell, Gordon, McLeod, Hamish, Cleare, S., Mitchell, G., Cleare, Seonaid, McLeod, H.J., Gumley, Andrew, White, R.G., McConville, Deirdre   +15 more
core   +1 more source

Clinically-relevant CNVs detected.

, 2022
Clinically-relevant CNVs detected.
Sian Ellard (25182), Kashyap A. Patel (12251414), Michael N. Weedon (10953860), Matthew N. Wakeling (12251417), Sarah E. Flanagan (8415405), Elisa De Franco (8231166), Matthew B. Johnson (1922497), Thomas W. Laver (8415384)   +7 more
core   +1 more source

A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml−1 and PI-RADS 1–3

Asian Journal of Andrology
We propose a strategy to reduce unnecessary prostate biopsies in Chinese patients with total prostate-specific antigen (tPSA) >10 ng ml−1 and Prostate Imaging Reporting and Data System (PI-RADS) scores between 1 and 3.
Qi-Fei Dong, Yi-Xun Liu, Yu-Han Chen, Yi-Fan Ma, Tao Zhou, Xue-Feng Fan, Xiang Yu, Chang-Ming Wang, Jun Xiao   +8 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Evaluatie van de verlengde pilotperiode van Detentieconcept Lelystad (DCL) [PDF]

, 2009
Detentieconcept Lelystad (DCL) is een pilotproject in het kader van de vernieuwingen die plaatsvinden binnen het transformatieproces De Nieuwe Inrichting van DJI. DCL is sinds januari 2006 operationeel. De pilotfase van het project is ondersteund met een
Nauta, O., Abraham, M., Jongebreur, W.
core   +1 more source

Utility of the prostate health index density for detecting clinically significant prostate cancer in patients with negative magnetic resonance imaging findings

Prostate International
Background: Multiparametric magnetic resonance imaging (MRI) is widely used in prostate cancer diagnosis; however, a significant proportion of clinically important cancers can be missed in patients with negative MRI findings.
Kazuhiko Oshinomi, Shota Kikuchi, Hirotaka Kishi, Anju Hayashi, Sho Okada, Masahiro Kurokawa, Toshiki Mugita, Yoshiki Tsunokawa, Tatsuki Inoue, Motoki Yamagishi, Yoshihiro Nakagami, Masakazu Nagata, Takashi Fukagai   +12 more
doaj   +1 more source

Mass Spectrometric Immunoassays in Characterization of Clinically Significant Proteoforms

Proteomes, 2016
Proteins can exist as multiple proteoforms in vivo, as a result of alternative splicing and single-nucleotide polymorphisms (SNPs), as well as posttranslational processing.
Olgica Trenchevska, Randall W. Nelson, Dobrin Nedelkov   +2 more
doaj   +1 more source