Results 201 to 210 of about 12,385,464 (249)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Linezolid MIC creep among clinically significant <i>S. aureus</i>: a retrospective eight-year study. [PDF]

Front Antibiot
Eshwarappa CS, Gs VS, Shettar SR, Maheshwarappa YD, Sumana MN, A T, Mahale RP, Gs S, Rao MR, Shankaregowda R, Chitaragi VB, R D, Sr S, Murthy NS, Sai BS, Kumar VV.   +15 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants. [PDF]

J Pathol Clin Res
Martínez Anaya D, Juárez-Velázquez MDR, Juárez Figueroa U, Dean M, Salas Labadía C, Valladares Coyotecatl M, Reyes León A, López Santiago N, Juárez Villegas L, Zapata Tarrés M, Pérez-Vera P.   +10 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Biologic Augmentation Improves Rotator Cuff Integrity But Not Clinically Significant Patient Outcomes: A Meta-Analysis of Randomized Controlled Trials. [PDF]

JB JS Open Access
Checketts JX, Daniels SD, Schiffman CJ, Matsen FA, Hsu JE.   +4 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Integrative and interpretable machine learning framework for early non-invasive detection of clinically significant liver fibrosis. [PDF]

Front Med (Lausanne)
Cao D, Wang J, Hou C, Zeng J, Tian B, Liu Y, Luo X, Tian J, Zhou M, Li P, Fang H, Liu Z, Gong Z.   +12 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Does More Mean Better? Treatment Intensity and Predictors of Clinically Significant Change in Suicidal Ideation During Dialectical Behaviour Therapy. [PDF]

Clin Psychol Psychother
Amestoy ME, Kolla N, Levy-Ajzenkopf J, Klein R, Uliaszek AA.   +4 more
europepmc   +1 more source