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Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

AI-enhanced micro-ultrasound improves detection of clinically significant prostate cancer at biopsy. [PDF]

BJUI Compass
Imran M, Brisbane WG, Su LM, Joseph JP, Shao W.   +4 more
europepmc   +1 more source

Clinically significant Klebsiella pneumoniae persistence in wastewater: co-occurrence of virulence and multidrug resistance genes. [PDF]

BMC Microbiol
Abdelgalel RR, Ibrahem RA, Ahmed ABF, Mohamed DS.   +3 more
europepmc   +1 more source

Development and Validation of a Novel Indicator for Differential Diagnosis of Clinically Significant Prostate Cancer Based on Comprehensive Hematological Testing. [PDF]

Diagnostics (Basel)
Wang F, Tang Y, Zhang G, Li J.
europepmc   +1 more source

Detection of clinically significant drug-drug interactions in serotonin syndrome: a multisource real-world data and pharmacovigilance study. [PDF]

Ther Adv Drug Saf
Xu S, Song Z, Wang D, Li Y, Wang E, Bai J, Wang X.   +6 more
europepmc   +1 more source

Subfoveal Choroidal Thickness in Clinically Significant Pseudophakic Cystoid Macular Edema: An Interocular Comparison with Contralateral Pseudophakic Eyes. [PDF]

Clin Ophthalmol
Demir K, Çelik E.
europepmc   +1 more source

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Effective dose 50 method as the minimal clinically important difference: Evidence from depression trials

Journal of Clinical Epidemiology, 2021
Glyn Lewis, Nicola Wiles, Daphne Kounali   +2 more
exaly