Results 1 to 10 of about 252,092 (216)

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +11 more sources

CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis

Experimental Hematology & Oncology, 2022
Objective Circular RNAs (circRNAs) play a critical role in the modulation of tumor metabolism. However, the expression patterns and metabolic function of circRNAs in chronic lymphocytic leukemia (CLL) remain largely unknown. This study aimed to elucidate
Zijuan Wu, Danling Gu, Ruixin Wang, Xiaoling Zuo, Huayuan Zhu, Luqiao Wang, Xueying Lu, Yi Xia, Shuchao Qin, Wei Zhang, Wei Xu, Lei Fan, Jianyong Li, Hui Jin   +13 more
doaj   +1 more source

Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia

Molecular Oncology, 2022
Ibrutinib exerts promising anticancer effects in chronic lymphocytic leukaemia (CLL). However, acquired resistance occurs during treatment, necessitating the exploration of underlying mechanisms.
Zijuan Wu, Luqiao Wang, Lei Fan, Hanning Tang, Xiaoling Zuo, Danling Gu, Xueying Lu, Yue Li, Jiazhu Wu, Shuchao Qin, Yi Xia, Huayuan Zhu, Li Wang, Wei Xu, Jianyong Li, Hui Jin   +15 more
doaj   +1 more source

Bipolar Disorder and Cardiovascular Risk in Rural versus Urban Populations in Colombia: A Comparative Clinical and Epidemiological Evaluation

Annals of Global Health, 2021
Background: Various multifactorial elements may contribute toward the urban and rural disparities in cardiovascular disease (CVD) risk, particularly among patients with psychiatric diseases.
Juan Pablo Forero, Alexander Ferrera, Jose Daniel Castaño, Sergio Ardila, Tanya Mesa, Dean Hosgood, Eugenio Ferro   +6 more
doaj   +1 more source

Single‐cell profiling‐guided combination therapy of c‐Fos and histone deacetylase inhibitors in diffuse large B‐cell lymphoma

Clinical and Translational Medicine, 2022
Background Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma. Histone deacetylase inhibitors (HDACis) have been widely applied in multiple tumours, but the expected efficacy was not observed in DLBCL.
Luqiao Wang, Zijuan Wu, Yi Xia, Xueying Lu, Ji Li, Lei Fan, Chun Qiao, Hairong Qiu, Danling Gu, Wei Xu, Jianyong Li, Hui Jin   +11 more
doaj   +1 more source

Bcl-2 Inhibition Induces a Synergistic Effect in Combination with Doxorubicin in Chronic Lymphocytic Leukemia [PDF]

ImmunoAnalysis, 2022
Background: Chronic lymphocytic leukemia (CLL), a common neoplastic disease, is associated with the accumulation of B-lymphocytes in the hematopoietic organs.
Mohammad Sadeghi, Koosha Sepasi, Amir Honarmand Alamdari, Ali Akbar Movasaghpour Akbari, Abbas Ali Hosseinpour Feizi, Sima Shahmohammadi Farid, Farhad Jadidi-Niaragh   +6 more
doaj   +1 more source

Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)

South African Journal of Oncology, 2021
Background: Chronic lymphocytic leukaemia (CLL) is a common lymphoproliferative disorder in developed countries. However, this condition is rare in Africa and there is a paucity of information on CLL, specifically on the continent.
Fungai Musaigwa, Ravnit Grewal, Akin Abayomi, Carmen C. Swanepoel   +3 more
doaj   +1 more source

Characterizing and prognosticating chronic lymphocytic leukemia in the elderly: prospective evaluation on 455 patients treated in the United States. [PDF]

, 2017
BACKGROUND: Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is \u3e 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community.
Bhushan, Shriya, Davids, Matthew S., Flick, E. Dawn, Flowers, Christopher R., Grinblatt, David L., Kiselev, Pavel, Lamanna, Nicole, Mato, Anthony, Nabhan, Chadi, Sharman, Jeff P., Sullivan, Kristen, Swern, Arlene S., Weiss, Mark A.   +12 more
core   +3 more sources

Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens. [PDF]

, 2015
BackgroundTo determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.MethodsTen CLL specimens and five normal peripheral blood CD19+ B ...
A Ameur, A Choudhury, A Hidalgo, A Rosenwald, AS Kamiguti, C Haslinger, C Soo, C Trapnell, C Trapnell, CJ David, DC Gilby, E Moon, E Moravcikova, F Colotta, F Talab, FC Kelleher, Gwen Jordaan, H Dohner, H Jiang, J Eswaran, J Vilpo, JC Marioni, JJ Dongen van, JP Venables, K Inada, K Zen, L Chen, L Wang, L Yang, LQ Zhang, M Crespo, M Rehli, M Shinohara, M Sultan, Matteo Pelegrini, ML Hermiston, MW Pfaffl, N Chiorazzi, NA Twine, O Bermudez, P Guglielmi, P Kapranov, PG Ferreira, Phillipp Nham, Q Huang, RA Higgins, RI Fernando, RK Gandhirajan, RN Damle, Ryan T. Phan, S Anders, S Courtois, S Decker, S Falt, S Ibrahim, S Liu, S Ma, S Ren, S Shen, Sanjai Sharma, SM Russell, SP Shah, SR Gunn, T Ormsby, TJ Hamblin, U Klein, V Quesada, Wei Liao, XS Puente, Y Pawitan, Y Pekarsky, Y Yu, Z Wang   +72 more
core   +1 more source

Another treatment option for relapsed or refractory chronic lymphocytic leukaemia. [PDF]

, 2017
We hereby report the clinical and biologic features of 33 of 4680 (0.7%) patients with chronic lymphocytic leukemia (CLL), managed at 10 Italian centers, who developed Hodgkin lymphoma (HL), a rare variant of Richter syndrome.
Mauro, Francesca Romana
core   +1 more source