Results 81 to 90 of about 252,165 (283)

Engineering extracellular vesicles as novel treatment options: exploiting herpesviral immunity in CLL

Journal of Extracellular Vesicles, 2019
Extracellular vesicles (EVs) are important mediators of cell–cell communication. Intriguingly, EVs can be engineered and thus exploited for the targeted transfer of functional proteins of interest. Thus, engineered EVs may constitute attractive tools for
Kathrin Gärtner, Manja Luckner, Gerhard Wanner, Reinhard Zeidler   +3 more
doaj   +1 more source

CLL Cells within the Proliferation Centers of the Patient Lymph Nodes Are Enriched for Notch Signaling, Thus NOTCH a Viable Target for CLL Therapy [PDF]

, 2023
S. K. Joshi, Matt Kilng, Furqan Mehdi, Mamta Shukla, Ashima Bhakri, Vipul Shukla, Nagendra K. Chaturvedi, Hamid Band, Javeed Iqbal   +8 more
openalex   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Should the current diagnostic criteria for CLL be reconsidered? A reply to Johnstone et al. “De‐diagnosing chronic lymphocytic leukaemia: An ethical and scientific case for changing diagnostic criteria” [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 2, February 2026.
Matos D.
europepmc   +2 more sources

EphrinA4 plays a critical role in α4 and αL mediated survival ofhuman CLL cells during extravasation [PDF]

, 2016
A role of endothelial cells in the survival of CLL cells during extravasation is presently unknown. Herein we show that CLL cells but not normal B cells can receive apoptotic signals through physical contact with TNF-α activated endothelium impairing ...
Alonso Colmenar, Luis Miguel, Flores, Miguel A., Fortea Gordo, Paula, García, Dolores, Ortuño, Francisco J., Soler, Gloria, Trinidad, Eva M., Zapata González, Agustín   +7 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Sustainability Across the Curriculum: Sharing Ideas From a Cross‐Canada Community of Practice

New Directions for Teaching and Learning, EarlyView.
ABSTRACT This chapter offers a “look‐back” one year after the formation of a Canadian sustainability education community of practice, and provides highlights of “sustainability across the curriculum” work that is taking place at Canadian Post‐Secondary Institutions, modeling benefits and challenges of cross‐campus organizing around sustainability ...
Janet Pivnick, Maria Spiliotopoulou
wiley   +1 more source

The ClpP activator ONC‐212 (TR‐31) inhibits BCL2 and B‐cell receptor signaling in CLL [PDF]

, 2021
Narjis Fatima, Yandong Shen, Kyle Crassini, Edwin J. Iwanowicz, Henk Lang, Donald S. Karanewsky, Richard I. Christopherson, Stephen P. Mulligan, Giles Best   +8 more
openalex   +1 more source

Audit Risk Disclosures, Targeted Inspections, and Audit Quality Information obligatoire sur les risques d'audit, inspections ciblées et qualité des audits

Contemporary Accounting Research, EarlyView.
ABSTRACT This article studies how the mandatory disclosure of audit risk and targeted regulatory inspections influence audit quality. We develop a model in which the auditor tests a firm's internal control over financial reporting before auditing the financial report and must issue an opinion on both.
Kyungha Lee, Rahul Menon
wiley   +1 more source

The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View

Journal of Experimental Pharmacology, 2021
Francesco Paolo Tambaro,1 Danilo De Novellis,1,2 William G Wierda3 1Unità Operativa di Trapianto di Midollo Osseo e Servizio Trasfusionale, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italy; 2Department of Precision Medicine ...
Tambaro FP, De Novellis D, Wierda WG
doaj