Results 71 to 80 of about 242,018 (254)
Medicinal Research Reviews, EarlyView.ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano +4 more
wiley +1 more source
Role of Patient’s Age and Comorbidities in Therapy of Chronic Lymphocytic Leukemia
Клиническая онкогематология, 2016 Background & Aims. New schemes of the antitumor therapy of CLL resulted in improvement of survival of relatively young patients. However, the therapy outcomes of elderly patients are still unsatisfactory.
Vladimir Vladimirovich Strugov +4 more
doaj +1 more source
International Journal of Cardiology: Heart & Vasculature, 2020 Introduction: Although the routine use of manual thrombus aspiration (MTA) in patients with ST-elevation myocardial infarction (STEMI) provides no benefit compared to conventional primary percutaneous coronary intervention (PCI), the use of this ...
Juan Hernando del Portillo +2 more
doaj +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre +5 more
wiley +1 more source
Sustainability Across the Curriculum: Sharing Ideas From a Cross‐Canada Community of Practice
New Directions for Teaching and Learning, EarlyView.ABSTRACT This chapter offers a “look‐back” one year after the formation of a Canadian sustainability education community of practice, and provides highlights of “sustainability across the curriculum” work that is taking place at Canadian Post‐Secondary Institutions, modeling benefits and challenges of cross‐campus organizing around sustainability ...
Janet Pivnick, Maria Spiliotopoulou
wiley +1 more source
Folate receptors detection based on the immobilization of folic acid onto Ti−W oxides thin film
Biosensors and Bioelectronics: XThe overexpression of folate receptors on cell surfaces is associated with abnormalities linked to epithelial cancers. This study reports on a capacitive biosensor that employs folic acid as a recognition molecule for the biosensing of folate receptors ...
Linda Bertel +3 more
doaj +1 more source
Robust Partial Multi‐Label Learning Under Dual Noise via Joint Subspace Learning
CAAI Transactions on Intelligence Technology, EarlyView.ABSTRACT Partial Multi‐label Learning (PML) deals with the ambiguity where each instance is annotated with a set of candidate labels, and only a subset of which is valid. While existing PML methods focus primarily on label disambiguation, they often rely on the assumption of a clean feature space.
Yuanjian Zhang +4 more
wiley +1 more source
Linking SLAMF1 to autophagy and sensitivity to therapy in chronic lymphocytic leukemia
Molecular & Cellular Oncology, 2018 We recently reported that expression of the costimulatory molecule and microbial sensor SLAMF1 (signaling lymphocytic activation molecule family 1, also known as CD150) is lost in chronic lymphocytic leukemia (CLL) patients characterized by a shorter ...
Cinzia Bologna, Silvia Deaglio
doaj +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Phosphorus (P) limitation may intensify plant competition. However, in severely P‐impoverished soils of south‐western Australia, cluster‐rooted Banksia attenuata (Proteaceae) can facilitate P acquisition of neighbouring species by mobilising tightly bound P from soil ...
Zhao Zhang +6 more
wiley +1 more source
Securing mechanism for the deployable column of the Hoop/Column antenna [PDF]
, 1983 The Column Longeron Latch (CLL) was designed and developed as the securing mechanism for the deployable, telescoping column of the Hoop/Column antenna. The column is an open lattice structure with three longerons as the principal load-bearing members. It
Ahl, E. L., Jr.
core +1 more source