Results 51 to 60 of about 34,539 (304)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Narrow bandwidth video Patent [PDF]

, 1969
Improvements in receiver of narrow bandwidth television ...
Bockwoldt, W. H.
core   +1 more source

High speed single photon detection in the near-infrared

, 2007
InGaAs avalanche photodiodes (APDs) are convenient for single photon detection in the near-infrared (NIR) including the fibre communication bands (1.31/1.55 $\mu$m).
A. J. Shields, A. W. Sharpe, B. E. Kardynal, Lopez-Higuera J. M., Shimizu O., Z. L. Yuan   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function

Cell Reports, 2015
Circadian rhythms regulate many aspects of physiology, ranging from sleep-wake cycles and metabolic parameters to susceptibility to infection. The molecular clock, with transcription factor BMAL1 at its core, controls both central and cell-intrinsic ...
Saskia Hemmers, Alexander Y. Rudensky
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Low power design of 16-bit synchronous counter by introducing effective clock monitoring circuits [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2023
Most of the system-level designs contain sequential circuits. Power optimization of these circuits at many levels is required to build a portable device with a long battery life.
Vivek Kumar Singh, Abhishek Nag, Apangshu Das, Sambhu Nath Pradhan   +3 more
doaj  

Synchronization of the Distributed Readout Frontend Electronics of the Baby MIND Detector [PDF]

, 2017
Baby MIND is a new downstream muon range detector for the WGASCI experiment. This article discusses the distributed readout system and its timing requirements.
Antonova, M., Asfandiyarov, R., Bayes, R., Benoit, P., Blondel, A., Bogomilov, M., Bross, A., Cadoux, F., Cervera, A., Chikuma, N., Dudarev, A., Ekelof, T., Favre, Y., Fedotov, S., Hallsjö, S.-P., Ichikawa, A. K., Izmaylov, A., Karadzhov, Y., Khabibullin, M., Khotyantsev, A., Kleymenova, A., Koga, T., Kostin, A., Kudenko, Y., Likhacheva, V., Martinez, B., Matev, R., Medvedeva, M., Mefodiev, A., Minamino, A., Mineev, O., Mitev, G., Nessi, M., Nicola, L., Noah, E., Ovsiannikova, T., Pais Da Silva, H., Parsa, S., Rayner, M., Rolando, G., Shaykhiev, A., Simion, P., Soler, P., Suvorov, S., Ten Kate, H., Tsenov, R., Vankova-Kirilova, G., Yershov, N.   +47 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Functional analysis of Casein Kinase 1 in a minimal circadian system.

PLoS ONE, 2013
The Earth's rotation has driven the evolution of cellular circadian clocks to facilitate anticipation of the solar cycle. Some evidence for timekeeping mechanism conserved from early unicellular life through to modern organisms was recently identified ...
Gerben van Ooijen, Matthew Hindle, Sarah F Martin, Martin Barrios-Llerena, Frédéric Sanchez, François-Yves Bouget, John S O'Neill, Thierry Le Bihan, Andrew J Millar   +8 more
doaj   +1 more source